丝裂原活化蛋白激酶与早产儿慢性肺疾病

早产儿慢性肺疾病是早产儿吸入高浓度氧、机械通气治疗和肺部感染后最常见的合并症.其详细的发病机制尚未完全明了,病理主要表现为早期的炎症反应,晚期的肺泡融合及间质成纤维细胞增生.丝裂原活化蛋白激酶(MAPK)是真核细胞内重要的信号传导通路,近来研究发现MAPK通过参与词节细胞炎症、增殖、分化、生存和凋亡等多种生物学行为,促进了早产儿慢性肺疾病的发生.

Mitogen activated protein kinase and chronic lung disease in preterm infants

Chronic lung disease is a very common complication caused by inhaled hyperoxia, mechanical ventilation and pulmonary infection in preterm infants. It shows early inflammation and late alveoli fusion with mesenchymal fibroblast proliferation. Mitogen activated protein kinase is a very important signal transduction pathway in eukaryotic cells.It plays an important role in the cell inflammation, proliferation, differentiation, survival and apoptosis, which may contributes to the chronic lung disease.