蝎毒对家兔凝血功能影响的研究

目的:研究蝎毒对家兔凝血功能的影响,以探讨蝎毒抑制凝血功能的机制。方法:10只家兔分别于给药前1h、给药后1h、给药后2h抽血1.8m l,检测凝血酶原时间、部分凝血酶原时间、纤维蛋白原含量。将给药后1h、给药后2h凝血酶原时间、部分凝血酶原时间、纤维蛋白原含量分别与给药前1h比较。结果:本实验中测定的凝血酶原时间、部分凝血酶原时间,在给药1h明显延长,与给药前相比具有差异显著性。在给药2h凝血酶原时间、部分凝血酶原时间比1h缩短,与给药前相比无差异显著性。结论:蝎毒对家兔凝血功能的影响除通过降低血液粘度外,还可能是蝎毒影响了凝血因子的功能所致。

Influence of Scorpion Venom on the blood Coagulation Function of Rabbits

Objective: Research the influence of Scorpion Venom on the blood coagulation function of rabbits and discuss the mechanism of Scorpion Venom restraining the blood coagulation function.Methods: All of 10 rabbits were abstracted 1.8ml blood 1 hour before rabbits recepting Scorpion Venom,1 hour and 2 hours after rabbits recepting Scorpion Venom.PT,APTT,FIB in blood of rabbits were examined.We compared the results of PT,APTT,FIB of 1 hour and 2 hours after rabbits recepting Scorpion Venom with the results of 1 hour before rabbits recepting Scorpion Venom.Results: The results of PT,APTT,FIB of 1 hour after rabbits recepting Scorpion Venom prolonged evidently.There was difference between the results of 1 hour after rabbits recepting Scorpion Venom and the results of 1 hour before rabbits recepting Scorpion Venom.There was no difference between the results of 2 hours after rabbits recepting Scorpion Venom and the results of 1 hour before rabbits recepting Scorpion Venom.Conclusion: The mechanism of Scorpion Venom restraining the blood coagulation probably function are that Scorpion Venom reduce blood viscosity and affects the function of blood coagulation factors.