人参皂甙对阿魏酸钠急性酒精中毒小鼠保护作用的影响

目的探讨人参皂甙(GS)对阿魏酸钠(SF)急性酒精中毒小鼠保护作用的影响。方法小鼠分别灌胃SF100 mg/kg、SF100 mg/kg GS50 mg/kg、SF100 mg/kg GS 100 mg/kg、SF100 mg/kg GS150 mg/kg,连续给药12 d。末次给药后30 min均灌胃7.11 g/kg乙醇。记录小鼠翻正反射消失和恢复时间;处死动物,取肝测组织丙二醛(MDA)含量、超氧化物歧化酶(SOD)及乙醇脱氢酶(ADH)的活性。结果和模型组比较, SF能明显延长小鼠翻正反射消失时间,并提高ADH活性;联合用药大、小剂量组MDA含量均低于模型组。结论SF对急性酒精中毒小鼠有较好的保护作用,GS与SF联合用药不能有效增强SF的保护作用。

Effect of Ginsenosides on Protection of Sodium Ferulate in Acute Alcoholism Mice

Objective To observe the effect of Ginsenosides on protection of Sodium ferulate in acute alcoholism mice.Method Different groups of mice were daily administered intragastrically with SF(100 mg/kg),SF GS(50mg/kg),SF GS(100 mg/kg),and SF GS(150 mg/kg),respectively,for 12 days.30 minutes after the last administration,the animals were given ethanol(7.11 g/kg)intragastrically.The tolerance time and the lasting time of the loss of righting reflex(LR)were recorded.Malonaldehyde(MDA)content,superoxide dismutase (SOD)and alcohol dehydrogenase(ADH)activity of the liver were assayed.Result Compared with the control group,SF obviously delayed the tolerance time of LR,shortened the lasting time of LR,and increased the hepatic ADH activity.Both the high and the low dose of GS used concomitantly with SF decreased MDA content in liver. Conclusion SF has significant protective effect on acute alcoholism mice,while the combination of SF and GS probably can not enhance the protection of SF against acute alcoholism.