重型颅脑外伤局灶低温与全身低温疗效的对比研究

目的：探究重型颅脑外伤局灶低温治疗与全身低温治疗的治疗效果。方法：采用Feeney自由落体改良模型（free fall improved model）,分别设定全身低温组（A组）、假颅脑外伤模型组（B组）、局灶低温组（C组）以及颅脑外伤模型组（D组）。对伤灶处以及与其相邻部位的脑组织进行检测,分别测定H2O、钠离子、钾离子的含量,观察比较各组间病理改变。结果：经检测发现,假颅脑外伤模型组受损神经元数为（2.2±0.4）个、全身低温组受损神经元数为（9.1±0.5）个、局灶低温组受损神经元数为（6.3±0.3）个、颅脑外伤模型组受损神经元数为（12.1±1.1）个;全身低温组和颅脑外伤模型组受损神经元数明显多于局灶低温组,差异具有统计学意义（P〈0.01）。全身低温组和颅脑外伤模型组H2O、钠离子的含量显著高于局灶低温组,差异具有统计学意义（P〈0.05）,而钾离子的含量明显低于局灶低温组,差异具有统计学意义（P〈0.01）。结论：局灶低温疗法相比较全身低温疗法在减少神经元损伤以及缓解脑水肿等方面具有明显优势,治疗效果显著,值得临床借鉴使用。

Severe Traumatic Brain Injury Hypothermia and Systemic Comparative Study of the Efficacy of Low Temperature

Objective：To explore the hypothermia treatment for severe traumatic brain injury and systemic hypothermia therapy the therapeutic effect of the two methods. Method：Feeney freefall improved model（free fall Improved model）,set the whole body hypothermia group（A group）,false traumatic brain injury model group（B）,the hypothermia group（C group）and traumatic brain injury model group（D）. Detecting wound stove at and adjacent parts of the brain tissue were measured in H 2 O,sodium ion,potassium ion content,the pathological changes were observed and compared among the groups. Result：After testing,found that the a false traumatic brain injury model group of damaged neurons to（2.2±0.4）,systemic hypothermia group of damaged neurons to（9.1±0.5）,hypothermia group of damaged neurons to（6.3±0.3）,cranial traumatic brain injury model group damaged neurons to（12.1±1.1）;impaired systemic hypothermia group and traumatic brain injury model group,which was significantly more than the number of neurons hypothermia group,there were significant differences,statistically significant（P 0.01）. Systemic hypothermia group and traumatic brain injury model group H 2 O,sodium ion content was significantly higher than the hypothermia group,which was statistically significant（P 0.05）,and potassium were significantly lower than the hypothermia group,with statistical significance（P 0.01）.Conclusion：Hypothermia therapy compared to whole body hypothermia therapy in reducing neuronal damage and alleviate cerebral edema has obvious advantages,a significant treatment effect,is worthy of learning to use.