血清高敏C-反应蛋白、胱抑素C在急性冠脉综合征患者中的表达及意义

目的：研究急性冠脉综合征（ACS）患者血清超敏C-反应蛋白（hs-CRP）、胱抑素C（Cys-C）表达水平的变化,探讨血清hs-CRP、Cys-C对急性冠脉综合征的临床诊断意义。方法：入选178例冠心病患者（其中稳定型心绞痛SAP组40例、不稳定型冠心病UAP组56例、NSTEMI组47例、STEMI组35例）,52例健康者作为对照组,采用乳胶凝集比浊法测定hs-CRP浓度,免疫比浊法测定血清Cys-C水平。结果：与对照组比较,急性冠脉综合征组hs-CRP水平均升高,且升高程度UAP组

The Clinical Changes and Significance of Serum High Sensitive C-reactive Protein and Cystatin C among Patients with Acute Coronary Syndrome

Objective：To investigate the clinical changes and significance of serum high sensitive C-reactive（hs-CRP）protein and cystatin C （Cys-C）among patients with acute coronary syndrome（ACS）. Method：178 patients with coronary heart disease（CHD）and 52 healthy subjects were divided in this study by a case-control study design. There were 40 patients with stable angina pectoris（SAP）,56 patients with unstable angina pectoris （UAP）,47 patients with non-ST segment elevated myoeardial infaretion（NSTEMI）,35 patients with ST segment elevated myoeardial infaretion（STEMI）. The concentration of serum hs-CRP was examined by latex agglutination test and Cys-C was examined by Turbidimetric immunoassay. Result：Compared with control group,The concentration of serum hs-CRP in ACS group significantly increased,and UAP groupNSTEMI groupSTEMI group（ P 0.05）. Compared with control group,the concentration of serum Cys-C significantly increased in UAP group and NSTEMI group（ P 0.05）,but STEMI group was lower（ P 0.05）. Conclusion：The level of serum hs-CRP and Cys-C have relationship with the degree of severity in ACS,and they have a certain value in ACS diagnosis.