美沙拉嗪及柳氮磺砒啶在治疗溃疡性结肠炎中的对比分析

目的：观察比较美沙拉嗪及柳氮磺砒啶治疗溃疡性结肠炎的临床疗效及其安全性。方法：提取2008年5月-2013年3月在本院治疗的50例溃疡性结肠炎患者的临床资料,其中25例运用美沙拉嗪治疗,设为观察组,另外25例运用柳氮磺砒啶治疗,设为对照组。比较两组患者治疗后的腹泻、腹痛、黏液血便等临床症状改善情况,评价并比较治疗后两组患者临床总有效率,观察比较两组患者治疗过程中不良反应发生情况。结果：治疗后两组的腹泻评分、腹痛评分、黏液血便评分均优于治疗前,比较差异有统计学意义（P〈0.05）;观察组治疗后的腹泻评分、腹痛评分、黏液血便评分均优于对照组治疗后,观察组临床症状改善程度优于对照组,比较差异有统计学意义（P〈0.05）;治疗后观察组总有效率为84.00%（21/25）,对照组总有效率为68.00%（17/25）,观察组优于对照组,比较差异有统计学意义（P〈0.05）;治疗过程中观察组并发症发生率为12%（3/25）,对照组并发症发生率为48.00%（12/25）,观察组并发症发生率优于对照组,比较差异有统计学意义（P〈0.05）。结论：美沙拉嗪及柳氮磺砒啶治疗溃疡性结肠炎都能明显改善患者的临床症状,但是美沙拉嗪有效率和安全性更高,更能显著的改善患者的临床症状,可优先选择使用。

Comparative Analysis of Mesalazine and Sulfasalazine Treatment of Ulcerative Colitis Pyridine

Objective：To observe and compare the clinical efficacy and safety of sulfasalazine mesalazine pyridine treatment of ulcerative colitis. Method：Extract May 2008-March 2013 in our hospital 50 cases of ulcerative colitis patients with clinical data,including 25 cases of the use of mesalazine treatment as the observation group. Another 25 cases of pyridine used sulfasalazine treatment as control group. After comparing two groups with diarrhea,abdominal pain,bloody mucus and other clinical symptoms,evaluate and compare the two groups after treatment clinical total effective, observe and compare the two groups during treatment adverse events. Result：After treatment,both groups rated diarrhea,abdominal pain score,bloody mucus scores were better than before the treatment,the comparison result was statistically significant（ P 0.05）;comparison between the two groups,the observation group’s,after treatment,diarrhea score,abdominal pain score,bloody mucus scores were better than those of control group after treatment, the degree of improvement of clinical symptoms observed group than in the control group,the difference was statistically significant（ P 0.05）. After treatment,the total effective rate was 84.00%（21/25）in the control group,the total effective rate was 68.00%（17/25）in the observation group,the results were statistically significant（ P 0.05）;treatment group was observed that the complication rate was 12%（3/25）and control group complication rate was 48.00%（12/25）,the results were statistically significant（ P 0.05）. Conclusion：Mesalazine and sulfasalazine pyridine can significantly improve the treatment of ulcerative colitis in patients with clinical symptoms,but mesalazine efficient and more secure,more significant improvement in clinical symptoms,it may be preferred be used.