低脂联素水平及其相关因素致胰岛素抵抗的通径分析

目的 探讨低脂联素水平及其相关因素在胰岛素抵抗（IR）发生中的影响大小及作用方式。方法 将2006年在济南市历下区人民医院体检者按是否有IR分为2组，其中IR组86例，非IR组87例，调查其血清脂联素水平及其相关因素，包括胰岛素水平、空腹血糖水平、身高、体重、体质指数（BMI）、吸烟史、吸烟指数、饮酒史、饮酒指数、家族史等情况，采用通径分析的方法探讨各因素在IR发生中的作用方式及影响大小。结果 BMI、吸烟指数和脂联素直接影响IR发生，标准结构系数分别为0.24、0.19、-0.17，经检验有统计学意义。家族史、性别、年龄、文化程度对IR产生间接影响。通径分析结果的剩余变异较大，解释力为14.07%。结论 低脂联素及相关因素不是人群IR发生主要影响因素。

Path analysis of adiponectin and its relative factors in Insulin resistance

Objective To explore the effect and style of adiponectin and other relative factors in insulin resistance(IR).Method A total of 86 cases of IR and 87 non-IR subjects were enrolled in this study.Serum adiponectin and its relative factors including insulin,blood fasting glucose,body height,body weight,smoking,drinking and family history were investigated.Path analysis explored the effect of these factors in insulin resistance.Results Path analysis showed that body mass index(BMI),smoking index and adiponectin had direct effects on IR,however a family history of diabetes mellitus,gender,age and culture had indirect effects on IR by affecting BMI,adiponectin and smoking.The results of path analysis indicated that the residual variation was on the high side,and the ability of explanation was only 14.07%.Conclusions Adiponectin and other relative factors are not the most important ones on IR in the subjects.