| 环氧化酶-2抑制剂防治肝癌的研究进展 |
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| 引用本文： | 李攀,赵春景.环氧化酶-2抑制剂防治肝癌的研究进展[J].中国药业,2004,13(12):25-27. |
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| 作者姓名： | 李攀 赵春景 |
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| 作者单位： | 重庆医科大学附属第二医院,重庆,400010 |
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| 摘 要： | 目的:介绍环氧化酶-2(COX-2)抑制剂预防和治疗肝癌的研究进展及其作用机制.方法:查阅近年来国内外相关文献.结果:COX-2抑制剂在体内和体外试验中均能显著抑制多种肝癌细胞的增殖,诱导其凋亡,并对肿瘤血管生成有抑制作用.结论:COX-2可能成为肿瘤治疗中的一个新靶点,COX-2抑制剂在肝癌的防治中有较好的应用前景,但其有效性和安全性还需进一步研究.
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| 关 键 词： | 环氧化酶-2 抑制剂 肝癌 |
| 文章编号： | 1006-4931(2004)12-0025-02 |
| 修稿时间： | 2004年5月8日 |
Research Advances in HCC Prevention and Treatment with COX-2 Inhibitors |
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| Li Pan,Zhao Chunjing.Research Advances in HCC Prevention and Treatment with COX-2 Inhibitors[J].China Pharmaceuticals,2004,13(12):25-27. |
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| Authors: | Li Pan Zhao Chunjing |
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| Abstract: | Objective:To introduce the progress and mechanism in HCC prevention and treatment with COX-2 inhibitors.Methods:The correlated articles in recent years have been reviewed.Results:Inhibitors of cyclooxygenase-2(COX-2) markedly inhibit the proliferation and induce the apoptosis of liver cancer cells in vitro and vivo.And they show a significant inhibition to tumorangiogenesis.Conclusion:COX-2 may be a new target for the therapy of cancer.COX-2 inhibitors have a good prospect in HCC chemoprevention and treatment though their effectiveness and safety need to be intensively studied. |
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| Keywords: | cyclooxygenase-2(COX-2) inhibitors hepatocellular carcinoma(HCC) |
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