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No evidence for association of the dysbindin gene [DTNBP1] with schizophrenia in an Irish population-based study |
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| Authors: | Morris Derek W McGhee Kevin A Schwaiger Siobhan Scully Paul Quinn John Meagher David Waddington John L Gill Michael Corvin Aiden P |
| Affiliation: | a Neuropsychiatric Genetics Group, Department of Genetics, Trinity College, Dublin 2, Ireland b Stanley Research Unit, St. Davnet's Hospital, Monaghan, Ireland c Department of Clinical Pharmacology, Royal College of Surgeons, 123 St. Stephen's Green, Dublin 2, Ireland |
| Abstract: | A recent family-based association study identified a putative association between variants in the dystrobrevin binding protein 1 (dysbindin) gene (DTNBP1) and schizophrenia. This study used a sample of 270 Irish pedigrees multiply affected with schizophrenia. We attempted to replicate these findings in an independent Irish sample of 219 schizophrenia cases and 231 controls. No evidence was found to suggest an association between the DTNBP1 gene and schizophrenia in our sample. Possible reasons for these findings are discussed. |
| Keywords: | Schizophrenia Dysbindin DTNBP1 Association |
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