| Changes of brain gray matter structure in Parkinson’s disease patients with dementia |
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| 作者姓名： | Jianguo Xia Jinlin Miu Hongbin Ding Xiuping Wang Hua Chen Juan Wang Juan Wu Jingli Zhao Huanxin Huang Weizhong Tian |
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| 作者单位： | Department of Radiology,Taizhou People’s Hospital;Department of Radiology,the Fourth People’s Hospital of Taizhou;Department of Medical Image Engineering,Medical School of Nantong University;Department of Radiology,Affiliated Hospital of Nantong University;Department of Geriatrics,Affiliated Hospital of Nantong University |
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| 基金项目： | supported by the Medical Clinical Science and Technology Development Fund of Jiangsu University,No.JLY20120122;Innovative Climb Program of Natural Science Foundation of Jiangsu Province,No.BK2008010;Natural Science Foundation of Nantong University,China,No.11Z001;Priority Academic Program Development of Jiangsu Higher Education Institutions |
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| 摘 要： | Voxel-based morphometry is gaining considerable interest for studies examining Parkinson’s disease dementia patients.In this study,12 patients with clinically defined Parkinson’s disease and dementia and 12 non-demented patients with Parkinson’s disease were examined using a T1WI three-dimensional fast spoiled gradient echo sequence.Gray matter data were analyzed using a voxel-based morphometry method and independent sample t-test based on Statistical Parametric Mapping 5 software.Differences in gray matter volume were represented with statistical parametric mapping.Compared with Parkinson’s disease patients without dementia,decreased gray matter volume in Parkinson’s disease dementia patients was observed in the bilateral superior temporal gyrus,bilateral posterior cingulate and left cingulate gyrus,right parahippocampal gyrus and hippocampus,right precuneus and right cuneus,left inferior frontal gyrus and left insular lobe.No increased gray matter volume was apparent.These data indicate that gray matter atrophy in the limbic system and cerebral neocortex is related to the presence of dementia.
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| 关 键 词： | neural regeneration neurodegenerative diseases neuroimaging voxel-based morphometry Parkinson’s disease dementia gray matter abnormality limbic system grants-supported paper neuroregeneration |
| 收稿时间： | 2013 Feb 11 |
Changes of brain gray matter structure in Parkinson's disease patients with dementia |
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| Jianguo Xia,Jinlin Miu,Hongbin Ding,Xiuping Wang,Hua Chen,Juan Wang,Juan Wu,Jingli Zhao,Huanxin Huang,Weizhong Tian.Changes of brain gray matter structure in Parkinson's disease patients with dementia[J].Neural Regeneration Research,2013,8(14):1276-1285. |
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| Authors: | Jianguo Xia Jinlin Miu Hongbin Ding Xiuping Wang Hua Chen Juan Wang Juan Wu Jingli Zhao Huanxin Huang Weizhong Tian |
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| Institution: | Jianguo Xia (Department of Radiology, Taizhou People's Hospital, Taizhou 225300, Jiangsu Province, China)； Jinlin Miu (Department of Radiology, the Fourth People's Hospital of Taizhou, Taizhou 225300, Jiangsu Province, China)； Hongbin Ding (Department of Radiology, Taizhou People's Hospital, Taizhou 225300, Jiangsu Province, China)； Xiuping Wang (Department of Radiology, Taizhou People's Hospital, Taizhou 225300, Jiangsu Province, China)； Hua Chen (Department of Radiology, Taizhou People's Hospital, Taizhou 225300, Jiangsu Province, China)； Juan Wang (Department of Medical Image Engineering, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China)； Juan Wu (Department of Radiology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China)； Jingli Zhao (Department of Radiology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China)； Huanxin Huang (Department of Geriatrics, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China)； Weizhong Tian (Department of Radiology, Taizhou People's Hospital, Taizhou 225300, Jiangsu Province, China)； |
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| Abstract: | Voxel-based morphometry is gaining considerable interest for studies examining Parkinson''s disease dementia patients. In this study, 12 patients with clinically defined Parkinson''s disease and dementia and 12 non-demented patients with Parkinson''s disease were examined using a T1WI three-dimensional fast spoiled gradient echo sequence. Gray matter data were analyzed using a voxel-based morphometry method and independent sample t-test based on Statistical Parametric Mapping 5 software. Differences in gray matter volume were represented with statistical parametric mapping. Compared with Parkinson''s disease patients without dementia, decreased gray matter volume in Parkinson''s disease dementia patients was observed in the bilateral superior temporal gyrus, bilateral posterior cingulate and left cingulate gyrus, right parahippocampal gyrus and hippocampus, right precuneus and right cuneus, left inferior frontal gyrus and left insular lobe. No increased gray matter volume was apparent. These data indicate that gray matter atrophy in the limbic system and cerebral neocortex is related to the presence of dementia. |
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| Keywords: | neural regeneration neurodegenerative diseases neuroimaging voxel-based morphometry Parkinson''s disease dementia gray matter abnormality limbic system grants-supported paper neuroregeneration |
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