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Differences in individual susceptibility affect the development of trigeminal neuralgia
Authors:Yusuf Kurtulu Duransoy  Mesut Mete  Emrah Akay  Mehmet Seluki
Institution:Yusuf Kurtulu(s) Duransoy (Department of Neurosurgery, Celal Bayar University School of Medicine, Manisa, Turkey); Mesut Mete (Department of Neurosurgery, Celal Bayar University School of Medicine, Manisa, Turkey); Emrah Ak(c)ay (Clinic of Neurosurgery, Anamur State Hospital, Mersin, Turkey); Mehmet Sel(c)uki1 (Department of Neurosurgery, Celal Bayar University School of Medicine, Manisa, Turkey);
Abstract:Trigeminal neuralgia is a syndrome due to dysfunctional hyperactivity of the trigeminal nerve, and is characterized by a sudden, usually unilateral, recurrent lancinating pain arising from one or more divisions of the nerve. The most accepted pathogenetic mechanism for trigeminal neuralgia is compression of the nerve at its dorsal root entry zone or in its distal course. In this paper, we report four cases with trigeminal neuralgia due to an unknown mechanism after an intracranial intervention. The onset of trigeminal neuralgia after surgical interventions that are unrelated to the trigeminal nerve suggests that in patients with greater individual susceptibility, nerve contact with the vascular structure due to postoperative pressure and changes in cerebrospinal fluid flow may cause the onset of pain.
Keywords:neural regeneration  peripheral nerve injury  asymptomatic vascular compression of the cranial nerves  cranial nerves  dorsal root entry zone  dorsal root exit zone  etiology  hyperactive dysfunction syndrome  individual susceptibility  risk factors  trigeminal neuralgia  neuroregeneration
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