Differences in individual susceptibility affect the development of trigeminal neuralgia |
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Authors: | Yusuf Kurtulu Duransoy Mesut Mete Emrah Akay Mehmet Seluki |
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Institution: | Yusuf Kurtulu(s) Duransoy (Department of Neurosurgery, Celal Bayar University School of Medicine, Manisa, Turkey); Mesut Mete (Department of Neurosurgery, Celal Bayar University School of Medicine, Manisa, Turkey); Emrah Ak(c)ay (Clinic of Neurosurgery, Anamur State Hospital, Mersin, Turkey); Mehmet Sel(c)uki1 (Department of Neurosurgery, Celal Bayar University School of Medicine, Manisa, Turkey); |
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Abstract: | Trigeminal neuralgia is a syndrome due to dysfunctional hyperactivity of the trigeminal nerve, and is characterized by a sudden, usually unilateral, recurrent lancinating pain arising from one or more divisions of the nerve. The most accepted pathogenetic mechanism for trigeminal neuralgia is compression of the nerve at its dorsal root entry zone or in its distal course. In this paper, we report four cases with trigeminal neuralgia due to an unknown mechanism after an intracranial intervention. The onset of trigeminal neuralgia after surgical interventions that are unrelated to the trigeminal nerve suggests that in patients with greater individual susceptibility, nerve contact with the vascular structure due to postoperative pressure and changes in cerebrospinal fluid flow may cause the onset of pain. |
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Keywords: | neural regeneration peripheral nerve injury asymptomatic vascular compression of the cranial nerves cranial nerves dorsal root entry zone dorsal root exit zone etiology hyperactive dysfunction syndrome individual susceptibility risk factors trigeminal neuralgia neuroregeneration |
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