Persimmon leaf flavonoid induces brain ischemic tolerance in mice |
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| Authors: | Mingsan Miao Xuexia Zhang Linan Wang |
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| Affiliation: | Mingsan Miao (Henan University of Traditional Chinese Medicine, Zhengzhou 450008, Henan Province, China); Xuexia Zhang (Henan University of Traditional Chinese Medicine, Zhengzhou 450008, Henan Province, China); Linan Wang (Henan University of Traditional Chinese Medicine, Zhengzhou 450008, Henan Province, China); |
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| Abstract: | The persimmon leaf has been shown to improve cerebral ischemic outcomes; however, its mechanism of action remains unclear. In this study, mice were subjected to 10 minutes of ischemic preconditioning, and persimmon leaf flavonoid was orally administered for 5 days. Results showed that the persimmon leaf flavonoid significantly improved the content of tissue type plasminogen activator and 6-keto prostaglandin-F1 α in the cerebral cortex, decreased the content of thromboxane B2, and reduced the content of plasminogen activator inhibitor-1 in mice. Following optical microscopy, persimmon leaf flavonoid was also shown to reduce cell swelling and nuclear hyperchromatism in the cerebral cortex and hippocampus of mice. These results suggested that persimmon leaf flavonoid can effectively inhibit brain thrombosis, improve blood supply to the brain, and relieve ischemia-induced pathological damage, resulting in brain ischemic tolerance. |
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| Keywords: | neural regeneration traditional Chinese medicine brain injury persimmon leaf flavonoid brain ischemic tolerance ischemic preconditioning mice cortex hippocampus pathology tissue type plasminogen activator plasminogen activator inhibitor-1 6-keto prostaglandin-F1 α thromboxane B2 grants-supported paper neuroregeneration |
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