慢支病人铜绿假单胞菌和不动杆菌对抗菌药的耐药性研究

目的 探讨我院呼吸内科慢性支气管炎急性发作期住院病人痰的铜绿假单胞菌和不动杆菌对20种抗菌药的耐药性。方法 回顾性分析2003年1月至2005年12月期间，慢性支气管炎急性发作期病人的痰培养所分离的铜绿假单胞菌136株和不动杆菌127株，其对20种药物敏感试验抗菌药的耐药率差值。结果 铜绿假单胞菌的2004，2005年耐药菌株比2003年明显增加。鲁氏不动杆菌的2004，2005年耐药菌株比2003年没有明显增加，鲍曼／溶血不动杆菌的2004，2005年耐药菌株比2003年明显增加（P〈0．05）。结论 铜绿假单胞菌和不动杆菌属的耐药比率逐年上升。据此，调控抗菌药的使用。

A study on drugs resistance to antibiotics of pseudomonas aeruginosa and acinetobacter isolated from the patients of chronic bronchitis

Objective To investigate the drug resistance of pseudomonas aeruginosa and acinetobacter isolated from the inpatients sputum of acute exacerbation of chronic bronchitis. Methods The data of drug susceptibility test to 20 antibiotics on pseudomonas aeruginosa strains 136 and acinetobacter strains 127 isolated from the inpatients sputum culture of acute exacerbation of chronic bronchitis were studied retrospectively (from January 2003 to December 2005). Then we analysed the changes of drug susceptibility every year respectively. Results In 2004 and 2005, the drugs resistance ratio of pseudomonas aeruginosa and baumanii or haemolyticus increased more significantly than that in 2003. But the drugs resistance ratio of acinetobacter iwoffi did not increase remarkably. Conclusion The drugs resistance ratio of pseudomonas aeruginosa and baumanii or haemolyticus increased year by year, so we must adjust the application of antibacterial agent on these grounds.