Seasonal variations in manifestations and activity of systemic lupus erythematosus |
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Authors: | Amit M; Molad Y; Kiss S; Wysenbeek AJ |
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Institution: | Department of Medicine B, Assaf Harofeh Medical Centre, Zerifin, Israel. |
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Abstract: | The purpose of the present study was to investigate a possible seasonal
pattern in various clinical and laboratory manifestations in a group of
systemic lupus erythamatosus (SLE) patients. One hundred and five SLE
patients were followed up during a 4 yr period. Data on each of the
clinical and laboratory variables examined, as well as the results of the
disease activity index (SLEDAI), were plotted against the month during
which they were obtained. Photosensitivity was the only variable to show a
seasonal pattern, having higher scores during the summer months (1.04 +/-
0.16 in July vs 0.58 +/- 0.12 in December). We were unable to show seasonal
patterns in any of the other variables examined. As a group, SLE patients
do not show any significant seasonal pattern in disease manifestations and
activity, except for photosensitivity. However, such a pattern may exist
for the individual patient.
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