|
|||||
|
|
| 慢性不可预知温和应激联合高脂饮食对大鼠血小板5-羟色胺的影响 | |
| 引用本文： | 乐发国,李娜,董燕,赵兴蓉,汪波,许秀峰. 慢性不可预知温和应激联合高脂饮食对大鼠血小板5-羟色胺的影响[J]. 中国动脉硬化杂志, 2011, 19(4) |
| 作者姓名： | 乐发国 李娜 董燕 赵兴蓉 汪波 许秀峰 |
| 作者单位： | 1. 昆明医学院附一院精神科,云南省昆明市,650032;重庆市精神卫生中心 2. 昆明医学院附一院精神科,云南省昆明市,650032 3. 重庆市精神卫生中心 |
| 基金项目： | 云南省教育厅青年教师基金项目(5Y0415C) |
| 摘 要： | 目的探讨慢性不可预知温和应激联合高脂饮食对血小板5-羟色胺的影响。方法 48只雄性SD大鼠随机均分为对照组、应激组、高脂组和高脂应激组,共饲养9周。高脂组和高脂应激组喂食高脂饲料,在实验开始时予维生素D3(60万U/kg)一次性腹腔注射,丙基硫氧嘧啶每天灌胃。对照组和应激组喂食基础饲料,在实验开始时予等量生理盐水一次性腹腔注射,生理盐水每天灌胃。第3周开始,应激组和高脂应激组给予慢性不可预知温和应激,共7周。在实验第9周末,取股动脉血测定血小板5-羟色胺含量。结果经析因分析,慢性不可预知温和应激对大鼠血小板5-羟色胺降低有明显影响(P<0.05),高脂饮食对血小板5-羟色胺无明显影响(P>0.05),二者之间无交互效应(P>0.05)。结论慢性不可预知温和应激降低大鼠血小板5-羟色胺含量,高脂饮食对大鼠血小板5-羟色胺没有影响,二者之间没有交互作用。 |
| 关 键 词： | 高脂饮食 应激 5-羟色胺 大鼠 |
Effect of Chronic Unpredictable Mild Stress on Platelet 5-Hydroxy Tryptamine in Rat Fed with High Fat Diet |
|
| YUE Fa-Guo,LI Na,DONG Yan,ZHAO Xing-Rong,WANG Bo,XU Xiu-Feng. Effect of Chronic Unpredictable Mild Stress on Platelet 5-Hydroxy Tryptamine in Rat Fed with High Fat Diet[J]. Chinese Journal of Arteriosclerosis, 2011, 19(4) | |
| Authors: | YUE Fa-Guo LI Na DONG Yan ZHAO Xing-Rong WANG Bo XU Xiu-Feng |
| Affiliation: | YUE Fa-Guo1,2,LI Na1,DONG Yan1,ZHAO Xing-Rong1,WANG Bo2,and XU Xiu-Feng1(1.Department of Psychiatry,The First Affiliated Hospital of Kunming Medical College,Kunming,Yunnan 650032,China,2.Chongqing Mental Health Center,China) |
| Abstract: | Aim To investigate the effects of chronic unpredictable mild stress(CUMS) on platelet(PLT)5-hydroxy tryptamine(5-HT) in rat fed with high fat diet(HFD) Methods 48 male SD rats were randomly and averagely divided into four groups: control group,CUMS group,HFD group and HFD+CUMS group,with 12 rats in each group.The rats in control group and CUMS group were fed with basic food and were once intraperitoneally injected with sodium chloride,and then fed with sodium chloride by intragastric administration once eve... |
| Keywords: | Dietary Fats Stress 5-Hydroxy Tryptamine Rats |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |