Mechanisms of toxicity mediated by neutrophil and eosinophil granule proteins期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Mechanisms of toxicity mediated by neutrophil and eosinophil granule proteins

Authors:	Lea Gigon Shida Yousefi Alexander Karaulov Hans-Uwe Simon

Institution:	1. Institute of Pharmacology, University of Bern, Bern, Switzerland;2. Department of Clinical Immunology and Allergology, Sechenov University, Moscow, Russia

Abstract:	Neutrophils and eosinophils are granulocytes which are characterized by the presence of granules in the cytoplasm. Granules provide a safe storage site for granule proteins that play important roles in the immune function of granulocytes. Upon granulocytes activation, diverse proteins are released from the granules into the extracellular space and contribute to the fight against infections. In this article, we describe granule proteins of both neutrophils and eosinophils able to kill pathogens and review their anticipated mechanism of antimicrobial toxicity. It should be noted that an excess of granules protein release can lead to tissue damage of the host resulting in chronic inflammation and organ dysfunction.

Keywords:	Cytotoxicity Eosinophil Granule protein Innate immunity Neutrophil α1-PI"} {"#name":"keyword" "$":{"id":"kwrd0040"} "$$":[{"#name":"text" "_":"α1-proteinase inhibitor α1-ACT"} {"#name":"keyword" "$":{"id":"kwrd0050"} "$$":[{"#name":"text" "_":"α1-antichymotrypsin ALP"} {"#name":"keyword" "$":{"id":"kwrd0060"} "$$":[{"#name":"text" "_":"anti-leukoprotease AMP"} {"#name":"keyword" "$":{"id":"kwrd0070"} "$$":[{"#name":"text" "_":"antimicrobial protein BPI"} {"#name":"keyword" "$":{"id":"kwrd0080"} "$$":[{"#name":"text" "_":"bactericidal/permeability-increasing protein CLC"} {"#name":"keyword" "$":{"id":"kwrd0090"} "$$":[{"#name":"text" "_":"Charcot-Leyden crystal protein ECP"} {"#name":"keyword" "$":{"id":"kwrd0100"} "$$":[{"#name":"text" "_":"eosinophil cationic protein EDN"} {"#name":"keyword" "$":{"id":"kwrd0110"} "$$":[{"#name":"text" "_":"eosinophil-derived neurotoxin EET"} {"#name":"keyword" "$":{"id":"kwrd0120"} "$$":[{"#name":"text" "_":"eosinophil extracellular trap EPO"} {"#name":"keyword" "$":{"id":"kwrd0130"} "$$":[{"#name":"text" "_":"eosinophil peroxidase ET"} {"#name":"keyword" "$":{"id":"kwrd0140"} "$$":[{"#name":"text" "_":"extracellular trap fMLP"} {"#name":"keyword" "$":{"id":"kwrd0150"} "$$":[{"#name":"text" "_":"N-formylmethionyl-leucyl-phenylalanine GPI"} {"#name":"keyword" "$":{"id":"kwrd0160"} "$$":[{"#name":"text" "_":"glycosylphosphatidylinositol hCAP"} {"#name":"keyword" "$":{"id":"kwrd0170"} "$$":[{"#name":"text" "_":"human cationic antimicrobial protein HNP"} {"#name":"keyword" "$":{"id":"kwrd0180"} "$$":[{"#name":"text" "_":"human neutrophil peptide LBP"} {"#name":"keyword" "$":{"id":"kwrd0190"} "$$":[{"#name":"text" "_":"LPS-binding protein MBP"} {"#name":"keyword" "$":{"id":"kwrd0200"} "$$":[{"#name":"text" "_":"major basic protein MMP"} {"#name":"keyword" "$":{"id":"kwrd0210"} "$$":[{"#name":"text" "_":"metalloproteinase MPO"} {"#name":"keyword" "$":{"id":"kwrd0220"} "$$":[{"#name":"text" "_":"myeloperoxidase mtDNA"} {"#name":"keyword" "$":{"id":"kwrd0230"} "$$":[{"#name":"text" "_":"mitochondrial DNA NET"} {"#name":"keyword" "$":{"id":"kwrd0240"} "$$":[{"#name":"text" "_":"neutrophil extracellular trap NGAL"} {"#name":"keyword" "$":{"id":"kwrd0250"} "$$":[{"#name":"text" "_":"neutrophil gelatinase-associated lipocalin PAF"} {"#name":"keyword" "$":{"id":"kwrd0260"} "$$":[{"#name":"text" "_":"platelet-activating factor PMN"} {"#name":"keyword" "$":{"id":"kwrd0270"} "$$":[{"#name":"text" "_":"polymorphonuclear leukocytes OS"} {"#name":"keyword" "$":{"id":"kwrd0280"} "$$":[{"#name":"text" "_":"reactive oxygen species SLPI"} {"#name":"keyword" "$":{"id":"kwrd0290"} "$$":[{"#name":"text" "_":"secretory leukoproteinase inhibitor TIMP-1"} {"#name":"keyword" "$":{"id":"kwrd0300"} "$$":[{"#name":"text" "_":"tissue inhibitor of metalloproteinase-1 TULIP"} {"#name":"keyword" "$":{"id":"kwrd0310"} "$$":[{"#name":"text" "_":"tubular-lipid binding protein
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