MRI-based brain structural changes following radiotherapy of Nasopharyngeal Carcinoma: A systematic review期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

MRI-based brain structural changes following radiotherapy of Nasopharyngeal Carcinoma: A systematic review

Authors:	N.S. Voon F.N. Lau R. Zakaria S.A. Md Rani F. Ismail H.A. Manan N. Yahya

Affiliation:	1. Diagnostic Imaging and Radiotherapy, Faculty of Health Sciences, National University of Malaysia, Jalan Raja Muda Aziz, 50300 Kuala Lumpur, Malaysia;2. Department of Radiotherapy and Oncology, National Cancer Institute, 62250 Putrajaya, Malaysia;3. Department of Radiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras, 56000 Kuala Lumpur, Malaysia;4. Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras, 56000 Kuala Lumpur, Malaysia;5. Department of Radiotherapy and Oncology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras 56000 Kuala Lumpur, Malaysia;6. Functional Image Processing Laboratory, Department of Radiology, Universiti Kebangsaan Malaysia Medical Centre, Cheras 56000 Kuala Lumpur, Malaysia;1. Département universitaire de la recherche et de l’enseignement, institut de cancérologie Lucien-Neuwirth, 42270 Saint-Priest-en-Jarez, France;2. Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 42270 Saint-Priest-en-Jarez, France;3. Laboratoire de radiobiologie cellulaire et moléculaire, UMR CNRS5822/IN2P3, IPNL, PRISME, 69622 Villeurbanne, France;1. Department of Radiation Oncology, Institut Curie, 26, rue d’Ulm, 75005 Paris, France;2. Department of Anesthesia Reanimation, Institut Curie, 75005 Paris, France;3. Department of Biostatistics, Institut Curie, 75005 Paris, France;1. Department of radiation oncology, Jean-Perrin center, 63011 Clermont-Ferrand, France;2. Department of medical physics, Jean-Perrin center, Clermont-Ferrand, France;3. Clermont Auvergne university, INSERM, U1240 IMoST, 63000 Clermont-Ferrand, France;4. Department of pathology, Clermont Auvergne university, Jean-Perrin center, 63011 Clermont-Ferrand, France;5. Department of neurosurgery, Clermont-Ferrand hospital, 63003 Clermont-Ferrand, France;1. Service de médecine interne, centre hospitalier universitaire de Besançon, Besançon, France;2. Institut de cancérologie de Bourgogne, Auxerre, France;3. Service d’oncologie médicale, centre hospitalier universitaire de Besançon, Besançon, France;4. Service de chirurgie orthopédique, centre hospitalier universitaire de Besançon, Besançon, France;5. Service de pneumologie, centre hospitalier universitaire de Besançon, Besançon, France;1. Service de radiothérapie, institut de cancérologie de Lorraine, 6, avenue de Bourgogne, 54511 Vand?uvre Lès Nancy, France;2. Service de radiophysique, institut de cancérologie de Lorraine, 6, avenue de Bourgogne, 54511 Vand?uvre Lès Nancy, France;3. Service de biostatistiques, institut de cancérologie de Lorraine, 6, avenue de Bourgogne, 54511 Vand?uvre Lès Nancy, France;4. Service de radiothérapie, centre Georges-François-Leclerc, 1, rue du Professeur-Marion, Dijon, France;5. Service de radiophysique, centre Georges-François-Leclerc, 1, rue du Professeur-Marion, Dijon, France

Abstract:	PurposeNasopharyngeal carcinoma (NPC) radiotherapy (RT) irradiates parts of the brain which may cause cerebral tissue changes. This study aimed to systematically review the brain microstructure changes using MRI-based measures, diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI) and voxel-based morphometry (VBM) and the impact of dose and latency following RT.MethodsPubMed and Scopus databases were searched based on PRISMA guideline to determine studies focusing on changes following NPC RT.ResultsEleven studies fulfilled the inclusion criteria. Microstructural changes occur most consistently in the temporal region. The changes were correlated with latency in seven studies; fractional anisotropy (FA) and gray matter (GM) volume remained low even after a longer period following RT and areas beyond irradiation site with reduced FA and GM measures. For dosage, only one study showed correlation, thus requiring further investigations.ConclusionDTI, DKI and VBM may be used as a surveillance tool in detecting brain microstructural changes of NPC patients which correlates to latency and brain areas following RT.

Keywords:	Nasopharyngeal Carcinoma Diffusion Tensor Imaging Diffusion Kurtosis Imaging Voxel-Based Morphometry Brain Carcinome nasopharyngé Imagerie du tenseur de diffusion Imagerie Kurtosis de diffusion Morphométrie à base de voxel Cerveau
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