Fasting and post-oral-glucose-load levels of methylglyoxal are associated with microvascular,but not macrovascular,disease in individuals with and without (pre)diabetes: The Maastricht Study |
| |
Authors: | NMJ Hanssen JLJM Scheijen AJHM Houben M van de Waarenburg TTJM Berendschot CAB Webers KD Reesink MMJ van Greevenbroek C van der Kallen NC Schaper MT Schram RMA Henry CDA Stehouwer CG Schalkwijk |
| |
Institution: | 1. Department of Internal Medicine, Maastricht University Medical Centre, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands;2. School for Cardiovascular Diseases (CARIM), Maastricht University Medical Centre, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands;3. Department of Ophthalmology, Maastricht University Medical Centre, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands;4. Department of Biomedical Engineering, Maastricht University Medical Centre, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands;5. Heart and Vascular Centre, Maastricht University Medical Centre, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands |
| |
Abstract: | AimsReactive dicarbonyl compounds, such as methylglyoxal (MGO), rise during an oral glucose tolerance test (OGTT), particularly in (pre)diabetes. Fasting MGO levels are associated with chronic kidney disease (CKD) and cardiovascular disease (CVD) in patients with poorly controlled type 2 diabetes mellitus (T2DM). Yet, whether fasting or post-OGTT plasma MGO levels are associated with vascular disease in people with (pre)diabetes is unknown.MethodsSubjects with normal glucose metabolism (n = 1796; age: 57.9 ± 8.2 years; 43.3% men), prediabetes (n = 478; age: 61.6 ± 7.6 years; 54.0% men) and T2DM (n = 669; age: 63.0 ± 7.5 years; 67.0% men) from the Maastricht Study underwent OGTTs. Plasma MGO levels were measured at baseline and 2 h after OGTT by mass spectrometry. Prior CVD was established via questionnaire. CKD was reflected by estimated glomerular filtration rate (eGFR) and albuminuria; retinopathy was assessed using retinal photographs. Data were analyzed using logistic regression adjusted for gender, age, smoking, systolic blood pressure, total-to-HDL cholesterol ratio, triglycerides, HbA1c, BMI and medication use. Odd ratios (ORs) were expressed per standard deviation of LN-transformed MGO.ResultsFasting and post-OGTT MGO levels were associated with higher ORs for albuminuria ≥ 30 mg/24 h fasting: 1.12 (95% CI: 0.97–1.29); post-OGTT: 1.19 (1.01–1.41)], eGFR < 60 mL/min/1.73 m2 fasting: 1.58 (95% CI: 1.38–1.82), post-OGTT: 1.57 (1.34–1.83)] and retinopathy fasting: 1.59 (95% CI: 1.01–2.53), post-OGTT: 1.38 (0.77–2.48)]. No associations with prior CVD were found.ConclusionFasting and post-OGTT MGO levels were associated with microvascular disease, but not prior CVD. Thus, therapeutic strategies directed at lowering MGO levels may prevent microvascular disease. |
| |
Keywords: | Cardiovascular disease Chronic kidney disease Diabetes Methylglyoxal 3-DG"} {"#name":"keyword" "$":{"id":"kw0030"} "$$":[{"#name":"text" "_":"3-deoxyglucosone AGEs"} {"#name":"keyword" "$":{"id":"kw0040"} "$$":[{"#name":"text" "_":"advanced glycation end-products BMI"} {"#name":"keyword" "$":{"id":"kw0050"} "$$":[{"#name":"text" "_":"body mass index CVD"} {"#name":"keyword" "$":{"id":"kw0060"} "$$":[{"#name":"text" "_":"cardiovascular disease eGFR"} {"#name":"keyword" "$":{"id":"kw0070"} "$$":[{"#name":"text" "_":"estimated glomerular filtration rate GO"} {"#name":"keyword" "$":{"id":"kw0080"} "$$":[{"#name":"text" "_":"glyoxal OGTT"} {"#name":"keyword" "$":{"id":"kw0090"} "$$":[{"#name":"text" "_":"oral glucose tolerance test HDL"} {"#name":"keyword" "$":{"id":"kw0100"} "$$":[{"#name":"text" "_":"high-density lipoprotein MGO"} {"#name":"keyword" "$":{"id":"kw0110"} "$$":[{"#name":"text" "_":"methylglyoxal UPLC-MS/MS"} {"#name":"keyword" "$":{"id":"kw0120"} "$$":[{"#name":"text" "_":"ultra-high-performance liquid chromatography/tandem mass spectrometry UAE"} {"#name":"keyword" "$":{"id":"kw0130"} "$$":[{"#name":"text" "_":"urinary albumin excretion |
本文献已被 ScienceDirect 等数据库收录! |
|