A fatal case of COVID-19-associated invasive pulmonary aspergillosis |
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| Authors: | Yuto Iwanaga Toshinori Kawanami Kei Yamasaki Hideki Sakakibara Issei Ikushima Hiroaki Ikegami Masahiro Tahara Kentaro Akata Hiroshi Mukae Kazuhiro Yatera |
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| Affiliation: | 1. Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan;2. Department of Respiratory Medicine, University Graduate School of Biomedical Sciences, Nagasaki City, Japan |
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| Abstract: | A 79-year-old Japanese man with polymyalgia rheumatica was admitted to hospital with coronavirus disease (COVID-19). On admission, he was treated with ciclesonide inhalation, ivermectin, and meropenem. He was intubated 6 days after admission, and methylprednisolone therapy was initiated (1000 mg/day). Hypoxemia and chest radiographic findings temporarily improved. However, chest computed tomography showed bilateral ground-glass attenuations, multiple nodules, and consolidation. Aspergillus fumigatus was cultured from the tracheal aspirate and he was diagnosed with COVID-19-associated invasive pulmonary aspergillosis (CAPA) and treated with liposomal amphotericin B. However, he died 28 days after admission. |
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| Keywords: | COVID-19 associated invasive pulmonary aspergillosis COVID-19 Acute respiratory distress syndrome |
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