黛力新治疗痛性糖尿病周围神经病变伴抑郁的疗效观察

目的：观察黛力新治疗痛性糖尿病周围神经病变伴抑郁的临床疗效。方法将80例伴有抑郁症状的2型糖尿病痛性周围神经病变患者随机分为A组（观察组）、B组（对照组），两组均静脉给予甲钴胺及α－硫辛酸治疗2周，观察组在此基础上加用黛力新口服2周。治疗前后测空腹血糖（FPG）、餐后2 h血糖（2hPG）及糖化血红蛋白（HbA1C），行四肢运动神经传导速度（ MNCV）、感觉神经传导速度（ SNCV）检查、汉密尔顿抑郁量表（ HAMD）评分、神经主觉症状问卷（ TSS）评分、视觉模拟评分（ VAS），观察药物副作用，评价临床疗效。结果治疗前两组患者FPG、2hPG、HbA1 C、MNCV、SNCV及HAMD、TSS、VAS分值均无显著性差异（P＞0．05）；治疗2周后与B组比较，A组MNCV、SNCV均较前改善（P＜0．05）；HAMD、TSS、VAS分值均较治疗前减低，差异有统计学意义（P＜0．05），总有效率A组（77．5％）明显高于B组（60．0％）（P＜0．05）。结论黛力新可有效改善痛性糖尿病周围神经病变的症状，同时可减轻抑郁。

Curative effect of deanxit in the treatment of painful diabetic peripheral neuropathy along with depression

Objective To observe the curative effect of deanxit in the treatment of painful diabetic peripheral neuropathy (PDPN). Methods 80 patients with PDPN were randomly divided into the observation group ( B group) and the control group ( A group) with 40 cases in each group.Both groups were received intravenously mecobalamin and α-lipoic acid.Moreover, B group was given deanxit orally for 2 weeks.The fasting plasma glucose (FPG), 2 hours plasma glucose (2hPG), glycosylated hemoglobin A1c ( HbA1 C) , motor nerve conduction velocity ( MNCV ) , sensory nerve conduction velocity ( SNCV ) , Hamilton Depression Scale ( HAMD) scores, total symptoms scores ( TSS) , visual analysis scale ( VAS) , drug’ s adverse effect, and clinical therapeutic effect were detected before and after treatment in both groups.Results There were no significant differences in FPG, 2hPG, HbA1 C, MNCV, SNCV, HAMD, TSS, and VAS sorces between A and B group.Compared with B group, MNCV and SNCV increased in A group (P<0.05), while HAMD, TSS and VAS scores significantly decreased (P<0.05) in A group after treatment of 2 weeks.The total effective rate of A group (77.5%) was significantly higher than that in B group (60.0%).Conclusion Deanxit can effectively relieve the clinical symptoms of PDPN, and the depression as well.