加味玉屏风散及单味中药对假丝酵母菌的体外抑菌作用

目的：观察加味玉屏风散及单味中药对假丝酵母菌的体外抑菌效果，旨在寻求中药在抗真菌方面的优势作用。方法用琼脂稀释法观察加味玉屏风散各组和单味中药黄连、茵陈、炙黄芪对104株假丝酵母菌的体外抑菌作用。结果玉屏风散＋黄连、玉屏风散＋黄连＋茵陈、黄连的抑菌效果较好，50％最低抑菌浓度（MIC50）分别为6．25、25．00、1．56 g· L－1，且对热带假丝酵母菌的抑菌效果最好，其次为光滑假丝酵母菌、白假丝酵母菌和葡萄牙假丝酵母菌，对近平滑假丝酵母菌抑菌效果较差。玉屏风散和炙黄芪仅对热带假丝酵母菌有一定抑菌效果，未发现茵陈对假丝酵母菌有抑菌作用。结论黄连及含黄连的加味玉屏风散对各种假丝酵母菌均有抑制作用，尤其是对耐药率较高的非白假丝酵母菌有较强的抑菌功效。这点对临床研究更有价值。

Inhibition test of the flavored yupingfeng powder and single traditional Chinese medicine against candida in vitro

Objective Through observing the in vitro inhibition effects of flavored yupinfeng powder and single traditional Chinese med-icine against candida, to seek the antifungal effects of traditional Chinese medicine ( TCM) .Methods Using AGAR dilution method to observe in vitro inhibition effect of the flavored yupingfeng powder and single traditional Chinese medicine( e.g., rhizoma coptidis , herba artemisiae, Radix Astragali preparata) to 104 strains of candida.Results Fungi inhibition effects of Yupingfeng powder +rhi-zoma coptidis, yupingfeng powder +rhizoma coptidis +herba artemisiae, and rhizoma coptidis are good.The minimal inhibitory con-centrations of 50%(MIC50) were 6.25, 25.00 and 1.56 g· L-1, respectively.Tropical candida showed best inhibitory response, fol-lowed by smooth-candida, white candida and portugal candida, while nearly smooth candida the worst.Yupingfeng powder and Radix Astragali preparata has certain antifungal effects only for tropical candida.Herba artemisiae didn’ t show any antifungal effects.Con-clusions Rhizoma coptidis and the flavored yupingfeng powder with coptis has strong inhibition efficacy for a variety of candida, espe-cially for the non-Candida albicans with higher percentages.It is more valuable for clinical research.