缺氧性呼吸抑制的中枢机制

呼吸对缺氧的反应都是双相的,即先兴奋后抑制。缺氧性呼吸兴奋的主要机制是氧分压降低刺激外周化学感受器而引起的反射性效应,但呼吸抑制的发生机制尚不十分清楚。本文主要介绍高级中枢、缺氧后脑血流量变化、缺氧对呼吸中枢神经元的实质性损害、神经递质和神经调质在缺氧性呼吸抑制过程中的作用。

Central Mechanism of Hypoxic Respiratory Depression

The responses of respiration to hypoxia is diphase,that is respiratory excitatory at first,then respiratory depression.The mechanism of hypoxic respiratory excitatory are reflective effects resulting from peripheral chemical sensors stimulated by decreased PaO2.but the pathogenesis of respiratory depression is not very clear.This article introduces the effect of high central nervous system,changes of cerebral blood flow after hypoxia,damage of hypoxia to neurons in the respiratory center,neurotransmitters and neuromodulators in hypoxic respiratory depression.