| 不同应激刺激后大鼠心脏、肝脏热休克蛋白(HSP70)的产生规律 |
| |
| 引用本文： | 张北奇,王燕凌,洪丽华,苗智慧. 不同应激刺激后大鼠心脏、肝脏热休克蛋白(HSP70)的产生规律[J]. 河北医药, 2003, 25(8): 563-565 |
| |
| 作者姓名： | 张北奇 王燕凌 洪丽华 苗智慧 |
| |
| 作者单位： | 050021,河北省医学科学院病生理研究室 |
| |
| 摘 要： | 目的 探讨热处理、心肌缺血及缺血预适应后大鼠心脏、肝脏热休克蛋白(HSP70)的产生规律。方法 采用聚丙烯酰胺凝胶电泳法测定不同应激刺激条件下各组动物心、肝组织产生HSP70的含量。结果 心肌组织对热休克、缺血等外源性应激刺激呈高敏感性，且随刺激形式的不同而产生的热休克蛋白含量也不同；而肝脏的反应则比较迟钝，对多数损伤反应的应答呈现一致性，但仍然显著高于对照组。结论 采用热休克蛋白作为研究指标时，应考虑到它的多源性和非特异性。慎下研究结论。
|
| 关 键 词： | 热处理 心肌缺血 缺血预适应 应激 热休克蛋白 聚丙烯酰胺凝胶电泳法 |
| 修稿时间： | 2003-02-20 |
The regular pattern of heat shock protein produced by different stimulates in heart and liver of rat |
| |
| ZHANG Beiqi,WANG Yanling,HONG Lihua,et al.. The regular pattern of heat shock protein produced by different stimulates in heart and liver of rat[J]. Hebei Medical Journal, 2003, 25(8): 563-565 |
| |
| Authors: | ZHANG Beiqi WANG Yanling HONG Lihua et al. |
| |
| Affiliation: | ZHANG Beiqi,WANG Yanling,HONG Lihua,et al.Department of Pathophysiology,Heibei Academy of Medical Sciences,Shijiazhuang 050021 |
| |
| Abstract: | Objective To study the regular pattern of heat shock protein(HSP70) produced after heat shock,myocardial ischemia or ischemia preconditioning in heart and liver of rat.Methods The content of HSP70 in heart and liver of rat was determined by electrophoresis.Results The myocardium was highly sensitive to heat shock, ischemia and other exotic stimulates,and the content of HSP70 was changed by different stimulates.The liver was low sensitive at the same condition,the content of HSP70 was not changed obviously, but which was much higher than that of control group.Conclusion It should be considered for the nonspecificity and polyphyly of HSP when it is used as the target for study. |
| |
| Keywords: | heat shock proteins myocardial ischemia ischemia preconditioning |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
