双路化疗与全身化疗治疗晚期胃癌的疗效观察

目的　比较双路化疗与全身化疗治疗晚期胃癌的疗效和毒副作用。方法　 81例晚期胃癌患者随机分为 2组 ,其中48例双路化疗 (MFP方案 ) ,33例全身化疗 (FAM方案 )。结果　MFP组和FAM组的有效率 (CR PR )分别为 45 .8%和 2 7.3 %(P >0 .0 5 ) ,2组的腹腔积液消退或减少率分别为 5 9.2 %和 2 5 .0 % (P <0 .0 5 ) ;2组的主要毒副作用是骨髓抑制 ,白细胞下降率 (Ⅰ～Ⅲ度 )分别为 43 .8%和 6 9.7% (P <0 .0 5 ) ,均无Ⅳ度下降者 ,无死亡病例。结论　 2组的疗效无显著性差异 ,但双路化疗组腹腔积液控制较好 ,毒副作用轻 ,有利于提高患者的生存质量。

Therapeutic Effect Comparison Between Two Route Chemotherapy and Intravenous Chemotherapy for Advanced Gastric Carcinorma

Objective To compare the therapeutic effects and toxicity of two route chemotherapy and intravenous chemotherapy in advanced gastric carcinorma.Methods 81 cases of advanced gastric carcinorma were divided randomly into two groups.48 cases recieved two route chemotherapy(MFP regimen),and other 33 cases recieved intravenous chemotherapy(FAM regimen).Results The data showed that the total rate of CR plus PR(MFP and FAM) was 45.8% and 27.3%,respectively(P> 0.05),the diminution rate of peritoneal effusions was 59.2% and 25.0%,respectively(P<0.05).The main toxicity was myelosuppression,the leukocytopenia rate was 43.8% and 69.7%,respectively(P<0.05),no fatal toxicity was encountered in both groups.Conclusion Two route chemotherapy has remarkable effect in the control of peritoneal effusions and lower hematologic toxicity.