非痴呆帕金森病患者事件相关电位变化的研究

 目的 通过事件相关电位(ERP)观察非痴呆帕金森病( PD)患者识别、区分熟悉和不熟悉人名的认知能力有无损害,以及年龄与PD患者认知功能的相关性.方法 采用EMS 32导脑电地形图机及其处理系统,以熟悉和不熟悉的人名作为诱发ERP的方法 ,观察32例PD患者事件相关电位P300波群的变化.结果 (1)PD组熟悉人名和不熟悉人名诱发的P3波幅之差较对照组明显缩小(P<0.05 );(2)PD组无论熟悉人名与不熟悉人名诱发的N2、P3潜伏期与患者年龄有显著正相关性(P <0.05～0.01).65岁以上PD组与对照组相比,N2、P3潜伏期显著延长(熟悉:P<0.01 ;P<0.01;不熟悉:P<0.01;P<0.01);熟悉人名诱发的P3波幅较对照组显著降低(P<0.01),熟悉人名与不熟悉人名诱发的波幅差距进一步缩短.结论 非痴呆PD患者识别熟悉人名的认知能力下降,并与年龄呈负相关.事件相关电位可检测 PD患者早期认知功能障碍.

Changes of event-related potentials in patients with nondemented Parkinson disease

Objective Applying the event-related potentials （ERPs） to evaluate whether the nondemented patients with Parkinson disease（PD） suffer from cognitive impairment of identifying and distinguishing familiar and unfamiliar names, and whether their cognitive function is affected by age. Methods Using familiar and unfamiliar names as inducting tasks, 32 nondemented patients with PD and 25 normal matched controls were observed by EMS 32 lead electroencephalic topographic apparatus with its process system. Results （ 1 ）The differences between the wave amplitudes evoked by familiar names and unfamiliar names were lower in the PD group than those in the control group（ P 〈 0.05）. （2）There was positive correlation between the ages of PD patients and the latencies of N2, P3 evoked by either familiar or unfamiliar names（ P 〈 0.05 ～ 0.01 ）. Compared with control subjects, the N2 and P3 latencies were markedly prolonged in PD patients over 65 years old （familiar： P 〈0.01; P 〈 0.01;unfamiliar： P 〈0.01; P 〈0.01）, and the wave amplitudes of P3 evoked by familiar names were significantly lower（ P 〈 0.01 ）, and further near to those induced by unfamiliar names. Conchusions The cognitive function of identifying familiar names is impaired in nondemented patients with PD, and associated with age negatively. ERPs can reflect early intellective dysfunction in PD patients.