COX-2 765基因多态性与环境因素在食管鳞癌发病中的交互作用

[目的]评价COX-2 765基因多态性与环境因素在食管癌的发生过程中是否存在交互作用.[方法]采用病例对照研究,病例组食管癌202例,对照组236名正常人.应用Taqman探针法检测COX-2 765位点单核苷酸多态性;运用相乘模型计算COX-2 765基因型与环境因素间的交互作用.[结果]病例组COX-2 765位点C等位基因频率为15.8％,对照组为3.0％,两组差异有统计学意义(x2=44.489,P＜0.001).携带COX-2 765 GC基因型的个体患食管癌的风险比COX-2 765 GG基因型增加(HR=7.354,95％CI:3.972～13.617).COX-2 765基因位点与反酸、住所周围有无工厂、住所周围有无空气污染、住所周围有无水污染、10年前水源和被动吸烟等因素的相乘模型交互作用有统计学意义(P＜0.05).[结论] COX-2 765 C等位基因可能为食管癌的遗传危险因素,且COX-2 765基因型与反酸、住所周围有无工厂、住所周围有无空气污染、住所周围有无水污染、10年前水源和被动吸烟存在相乘模型交互作用.

Interaction Between COX-2 765 Polymorphism and Environmental Factors in Pathogenesis of Esophageal Squamous Cell Carcinoma

[Purpose] To investigate the possible interaction between COX-2 765 polymorphism and environmental risk factors in the pathogenesis of esophageal squamous cell carcinoma.[Methods] According to the case-control design,202 cases with esophagal cancer and 236 controls were enrolled in this study.COX-2 765 single nucleotide polymorphism was detected with Taqman probe,and multiplicative model was used to analyze interaction between COX-2 765 genotype and environmental factors.[Results] Allele frequency of C of COX-2 765 15.8％ in case group,was higher than that in control group (15.8％ vs 3.0％,x2=44.489,P＜0.001).The person with COX-2 765 GC genotype had a higher risk for esophageal squamous cell carcinoma than that with COX-2 765 GG genotype(HR=7.354,95％CI:3.972～ 13.617).Multiplicative model interaction was found that there were interactions of COX-2 765 genotype with acid reflux,factories,air and water pollution around residence,and passive smoking (P＜0.05).[Conclusion] COX-2 765 C allele gene may be associated with esophageal cancer.Multiplicative model interaction exists between COX-2 765 genotype and acid reflux,factories,air,water pollution around residence,and passive smoking.