2013~2015年南京地区常用抗真菌药利用分析

摘 要 目的：了解南京地区抗真菌药的利用情况和发展趋势，为临床合理使用抗真菌药提供参考。方法: 采用限定日剂量法，对本地区34家医院2013~2015年抗真菌药的销售金额、用药频度（DDDs）和限定日费用（DDC）等进行回顾性分析。结果: 2013~2015年抗真菌药的销售金额逐年上升，增长率最高达41.13%；三唑类药物的销售金额连续三年居首位，占所有抗真菌药销售金额的60%以上；2013~2015年伏立康唑、氟康唑、伊曲康唑和卡泊芬净居销售金额的前4位；克霉唑外用剂型、伊曲康唑口服剂型保持DDDs的前2位；临床使用量较大的抗真菌药集中于唑类和烯丙胺类；DDC值居前三位的是卡泊芬净、米卡芬净和伏立康唑注射液。结论:2013~2015年抗真菌药的临床使用量持续攀升，侵袭性真菌感染是高危致命因素，合理使用抗真菌药是临床治疗的首要原则。

Utilization Analysis of Antifungal Drugs in Nanjing Area during 2013 and 2015

ABSTRACT Objective: To evaluate the utilization of antifungal drugs in Nanjing area, and provide clinical reference for the rational use of antifungal drugs. Methods: According to the sales data of antifungal drugs in 34 hospitals in Nanjing area from 2013 to 2015, the utilization of antifungal drugs was analyzed in respects of consumption sum, DDDs and DDC. Results:The consumption sum and use of antifungal drugs increased year by year. The maximum amount of consumption sum growth rate was 41.13%. Triazole drugs occupied the top of consumption sum during the past three years, and the sales amount accounted for more than 60% of all. In term of consumption sum, voriconazole, fluconazole, itraconazole and caspofungin ranked top 4 of antifungal drugs. Clotrimazole topical preparations and oral itraconazole ranked top 2 of DDDs, and caspofungin, micafungin and voriconazole ranked top 3 of DDC.Conclusion:The clinical application of antifungal drugs continues to increase during 2013 and 2015. Invasive fungal infection is a lethal factor at high risk. Choosing reasonable, effective, safe and economic of antifungal drugs is the first principle in clinical treatment.