丹皮酚温度敏感型凝胶的制备及体外性能探索

目的：制备丹皮酚温敏凝胶并进行体外初步性能的研究。方法：采用试管倒转法考察泊洛沙姆407、泊洛沙姆188浓度对胶凝温度的影响；采用旋转式粘度计，考察凝胶的粘度；用无膜溶出法考察其体外溶蚀及释药特性。结果：泊洛沙姆407 的胶凝温度随着浓度的升高而降低，泊洛沙姆407的胶凝温度随着体系中加入的泊洛沙姆188的浓度的增加而升高；丹皮酚温敏凝胶体外320min累积释药70%，凝胶溶蚀与药物释放同时进行，没有突释现象。结论：丹皮酚温敏凝胶制备工艺简单，使用方便，具有明显的缓释效应。

Preparation and in Vitro Properties of Paeonol Thermo Sensitive Gel

This study aimed at preparing paeonol thermosensitive gel and preliminary exploring its properties in vitro.Tube inversion method was adopted to investigate the effects of concentrations of poloxamer 407 and poloxamer 188 on gelation temperature.Then,viscosity of the gel was detected by rotary viscometer,and in vitro erosion and drug release characteristics of the gel by no film stripping method.As a result,the gelation temperature of poloxamer 407 decreased with the increase of its concentration,while gelation temperature of poloxamer 407 increased with the accelerating concentration of poloxamer 188.The cumulative drug release of paeonol thermo sensitive gel was up to 70% in 320min.Gel dissolution and drug release were simultaneously performed without burst release phenomenon.It was concluded that the preparation process of paeonol thermo sensitive gel was simple and easy to use with the overt effect of sustainedrelease.