应用FRAX评价2型糖尿病对老年男性骨质疏松性骨折风险的影响

目的探讨2型糖尿病对老年男性骨质疏松性骨折风险的影响。方法收集138例老年男性2型糖尿病患者作为糖尿病组,140名血糖正常老年男性作为对照组,比较两组间的一般资料、血糖、骨质疏松患病率、骨密度以及骨折风险的差异,从而分析2型糖尿病对老年男性骨质疏松性骨折风险的影响。结果糖尿病组骨质疏松的患病率显著高于对照组(P0.05),糖尿病组患有骨量减少的比例与对照组比较差异无统计学意义(P0.05),糖尿病组的腰椎骨密度、股骨颈骨密度显著低于对照组(P0.05),糖尿病组的10年发生主要部位骨质疏松骨折的概率和10年发生髋部骨折概率显著高于对照组(P0.05)。结论 2型糖尿病可增加老年男性患者骨质疏松的患病率,会降低患者骨密度,增加患者骨折的风险,应采取措施积极加强预防和干预。

Evaluation of the impact of type 2 diabetes mellitus on osteoporotic fracture risk in elderly men by FRAX

Objective To study the effect of type 2 diabetes mellitus (T2DM) on osteoporotic fracture risk of senile men. Methods A total 138 T2DM senile men were assigned into study group, and 140 healthy men into control group. General information, blood glucose, prevalence rate of osteoporosis, bone mineral density (BMD) and fracture risk between the two groups were compared for analyzing the effect of T2DM on osteoporotic fracture risk of senile men. Results The prevalence rate of osteoporosis in the study group was higher than that in the control group (P<0.05). There was no significant difference in the rate of osteopenia between the 2 groups. BMD of the lumbar vertebrae and the femoral neck in the study group was lower than that in the control group (P<0.05). The ten year probability of major osteoporotic fracture and hip fracture in the study group were higher than those in the control group (P<0.05). Conclusion T2DM increases the prevalence rate of osteoporosis and decreases BMD in senile men, resulting in high risk of osteoporotic fracture. Prevention and intervention of osteoporotic fracture should be strengthened in this population.