2型糖尿病视网膜病变合并骨质疏松患者血清25(OH)D与Betatrophin的关系

目的探讨2型糖尿病视网膜病变(type 2 diabetes mellitus retinopathy,T2DR)合并骨质疏松(osteoporosis,OP)患者血清25羟维生素D25-hydroxy vitamin D,25(OH)D]与Betatrophin之间的关系。方法选取2016年11月-2017年9月在我院内分泌科就诊的2型糖尿病(Type 2 Diabetes Mellitus,T2DM)患者100例,通过非散瞳眼底检查将T2DM患者分为并发DR组35例和非DR组65例,再据骨密度测定结果将DR组分为合并骨质疏松组(T2DM+DR+OP组)15例及非骨质疏松组(T2DM+DR组)20例,将非DR组分为合并骨质疏松组(T2DM+OP组)25例及非骨质疏松组(T2DM组)40例。同期随机筛选健康体检中心不同年龄健康受试者60例为正常对照(normal control,NC)组。酶联免疫吸附(ELISA)法测定所有受试者血清中Betatrophin水平,电化学发光法测定25(OH)D水平。结果与非骨质疏松的2型糖尿病视网膜病变患者相比,合并骨质疏松的2型糖尿病视网膜病变患者血清25(OH)D水平降低,Betatrophin水平升高,差异具有统计学意义(P0.05)。结论血清中25(OH)D水平降低及Betatrophin水平升高,可能共同参与了2型糖尿病视网膜病变、骨质疏松的发生发展。

Relationship between serum 25(OH)D and Betatrophin in patients with type 2 diabetic mellitus retinopathy combined with osteoporosis

Objective To investigate the relationship between serum 25-hydroxy vitamin D 25(OH)D] and Betatrophin in patients with type 2 diabetic mellitus retinopathy (DR) combined with osteoporosis (OP). Methods One hundred patients with type 2 diabetes mellitus (T2DM) were selected from the Department of Endocrinology in our hospital from November 2016 to September 2017. the T2DM patients were divided into DR group with (35 cases) and non-DR group (65 cases) by non-mydriatic fundus examination. Then according to the bone mineral density measurement results, DR group was divided into OP group (group T2DM+DR+OP, 15 cases) and non-OP group (group T2DM+DR, 20 cases). Non-DR group was divided into patients with OP group (T2DM+OP group, 25 cases) and non-OP group (T2DM group, 40 cases). At the same time, 60 healthy subjects of different ages were randomly selected as normal control (NC) group. Enzyme linked immunosorbent assay (ELISA) was used to determine the serum levels of Betatrophin in all subjects. 25(OH)D levels were determined with electrochemiluminescence. Results Compared with those in DR patients with non-OP, 25 (OH) D levels decreased and Betatrophin level increased in DR patients with OP, and the difference was statistically significant. Conclusion The decrease of serum 25 (OH) D level and the elevation of Betatrophin level may be involved in the development of type 2 diabetic mellitus retinopathy and osteoporosis.