生长相关蛋白-43在间质性膀胱炎患者膀胱黏膜表达的研究

目的探讨生长相关蛋白43（GAP-43）在间质性膀胱炎/膀胱疼痛综合征（IC/BPS）患者膀胱黏膜组织中的表达情况，以及与患者症状严重程度之间的相关性。 方法通过免疫组织化学法检测GAP-43在31例IC/BPS患者膀胱组织中的表达情况，并通过入院时对全部病例进行症状评分（ICSI），问题评分（ICPI）和盆腔疼痛、尿频/尿急症状评分(PUF)，评估GAP-43的表达与IC/BPS患者症状严重性之间的相关性。 结果31例IC/BPS患者中，ICSI 13～19分，平均（16±3）分；ICPI 7～16分，平均（12±1）分。PUF 16～25分，平均（20±2）分。症状总分37～57分，平均（46±4）分。IC/BPS患者膀胱组织中GAP-43表达水平免疫组化评分为0～6分，平均（5.2±0.3）分。GAP-43在IC/BPS患者膀胱组织中的表达程度与患者的症状严重程度（ICSI+ICPI、PUF、ICSI+ICPI+PUF）之间成正相关（相关系数=0.469、0.611、0.426），具有统计学意义（P=0.046、0.039、0.008）。 结论GAP-43在IC/BPS患者膀胱组织中的表达与患者的症状严重程度成正相关，提示GAP-43在IC/BPS的发病机制中可能起着一定的作用。

The expression of growth associated protein 43 in bladder tissue of patients with interstitial cystitis

ObjectiveTo explore the growth associated protein (GAP-43) expression in patients with interstitial cystitis/bladder painful syndrome (IC/BPS) and the correlation between symptoms. MethodsThrough the immune histochemical method to detect GAP-43 expression in bladder tissue of 31 patients with IC/BPS, ICSI, ICPI and PUF score before treatment, and the ralationship between GAP-43 expression and patient's symptoms were assessed. ResultsOf 31 IC/BPS patients, ICSI scores were ranged from 13 to 19 (mean 16±3), ICPI scores were ranged from 7 to 16 (mean 12±1), PUF scores were ranged from 16 to 25 (mean 20±2), symptom scores were ranged from 37 to 57 (46±4). The expression of GAP-43 immune histochemical scores were ranged from 1 to 6 (mean 5.2 ± 0.3) points. There was a positive correlation between GAP-43 expression levels in the bladder tissue and symptom severity of IC/BPS patients, correlation coefficients were 0.469, 0.611, 0.426 respectively, P value were 0.046, 0.039, 0.008 respectively. ConclusionGAP-43 expression in bladder tissue of IC/BPS patients are positively related to the patient's symptom severity, suggesting that GAP-43 expression in bladder tissue may be involved in the pathogenesis of IC/BPS.