Inhibitory effects of Pfaffia paniculata (Brazilian ginseng) on preneoplastic and neoplastic lesions in a mouse hepatocarcinogenesis model |
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| Authors: | da Silva Tereza Cristina Paula da Silva Ana Akisue Gokithi Luis Avanzo José Kazumi Nagamine Márcia Fukumasu Heidge Matsuzaki Patrícia César Raspantini Paulo Haraguchi Mitsue Lima Górniak Silvana Dagli Maria Lúcia Zaidan |
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| Affiliation: | 1. Department of Pathology, Faculty of Veterinary Medicine and Zootechny, University of São Paulo, Av. Prof. Dr Orlando Marques de Paiva, 87, CEP 05508-900 São Paulo, SP, Brazil;2. Academic Unit of the Biological Sciences Area, Faculty of Pharmaceutical Sciences, University of São Francisco, Campus of Bragança Paulista, SP, Brazil;3. CEPTOX Research Centre for Veterinary Toxicology of the Department of Pathology, Faculty of Veterinary Medicine and Zootechny, University of São Paulo, Av. Duque de Caxias Norte 225, CEP 13635-900 Pirassununga, SP, Brazil;4. Section of Pharmacology, Division of Animal Biology, Biological Institute of São Paulo, CP 12.898, Av. Conselheiro Rodrigues Alves, 1252, CEP 04014-002 São Paulo, SP, Brazil |
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| Abstract: | Studies have been demonstrating Pfaffia paniculata root (Brazilian ginseng) anticarcinogenic activities. We evaluated its chemopreventive effects on preneoplastic hepatic lesions. BALB/c aged-15 days received 10mug/g of diethylnitrosamine carcinogen, i.p. They were fed with the powdered root added to the diet: 0.5, 2 or 10% during 27 weeks. After being sacrificed, the macroscopic lesions in the livers were examined. Preneoplastic or neoplastic lesions were measured, quantified and classified morphologically. The treatment reduced the incidence, mean area and number of lesions, indicating an inhibitory effect of these roots on hepatocarcinogenesis promotion or progression steps. |
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