心力衰竭患者血浆BNP水平变化与临床分析

目的探讨心力衰竭(HF)患者血浆B型尿钠肽(BNP)改变及其临床意义。方法采用美国BiositeDiagnostics公司出品的B-型利钠肽试剂盒和TriageBNP测试仪分别测定90例HF(NYHAⅡ、Ⅲ、Ⅳ)患者和30例健康对照组的血浆BNP水平,并进行对照分析。结果 HF组总体血浆BNP水平明显高于对照组(P<0.01),NYHAⅡ级心功能时血浆BNP明显高于对照组(P<0.01),且Ⅱ、Ⅲ、Ⅳ级组间血浆BNP依次递增(P<0.01)。血浆BNP在HF控制后明显低于HF控制前(P<0.01)。结论血浆BNP的水平对HF的诊断、严重程度和预后评价有重要价值。

Clinical Analysis of the Change of Plasma BNP Levels in Patients with Heart Failure

Objective To study the clinical significance of the changes of plasma BNP 1evels inpatients with heart failure（HF）. Methods Plasma BNP levels in 90patients with HF（NYNAⅡ、Ⅲ、Ⅳ）and 30 controls were determined with rapid fluorescence immunoassay. Results The plasma BNP levels in patients with HF were significantly higher than controls （P0.01）.The plasma BNP levels in patients with cardiac function NYHAⅡ were significantly higher than controls（P0.01）. As the cardiac function deteriorated from NYNAⅡ to NYNAⅣ, The BNP levels increased consecutively with significant differences from each other（P0.01）. The plasma BNP levels is low when HF was cured（P0.01）. Conclusion Determination of plasma BNP levels in patients with HF were helpful to the study of the severity and prognosis of disease.