| 高压氧联合盐酸多奈哌齐治疗老年期痴呆临床研究 |
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| 引用本文： | 袁良津,施雪英.高压氧联合盐酸多奈哌齐治疗老年期痴呆临床研究[J].安徽医学,2010,31(8):889-892. |
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| 作者姓名： | 袁良津 施雪英 |
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| 作者单位： | 安徽医科大学附属安庆医院神经内科,安庆,246003;安徽医科大学附属安庆医院神经内科,安庆,246003 |
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| 摘 要： | 目的观察高压氧联合盐酸多奈哌齐治疗老年期痴呆（elderly dementia,ED）的临床疗效。方法 82例阿尔茨海默病（Alzheimer＇s disease,AD）和93例血管性痴呆（vascular dementia,VD）患者,随机分为高压氧、盐酸多奈哌齐、高压氧＋盐酸多奈哌齐、吡拉西坦组。比较治疗前后各组简易精神状态量表（MMSE）、韦氏成人记忆量表（WMS）、生活功能量表（ADL）的评分。结果治疗后高压氧、盐酸多奈哌齐、高压氧＋盐酸多奈哌齐组其MMSE、ADL、WMS评分均较治疗前明显改善,且均优于吡拉西坦对照组,高压氧＋盐酸多奈哌齐治疗组又优于单纯盐酸多奈哌齐组和高压氧治疗组。结论高压氧联合盐酸多奈哌齐应用可明显改善AD与VD患者的MMSE、WMS、ADL评分,疗效提高,值得临床进一步推广应用。
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| 关 键 词： | 盐酸多奈哌齐 高压氧 老年期痴呆 |
Clinical effect of donepezil hydrochioride and the high pressure oxygen ont the elderly dementia |
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| Yuan Liangjin,Shi Xueying.Clinical effect of donepezil hydrochioride and the high pressure oxygen ont the elderly dementia[J].Anhui Medical Journal,2010,31(8):889-892. |
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| Authors: | Yuan Liangjin Shi Xueying |
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| Institution: | Yuan Liangjin,Shi Xueying Department of Neurosurgery,Anqing Hospital Affiliated to Anhui Medical University,Anqing 246003,China |
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| Abstract: | Objective To investigate the clinical effect of donepezil hydrochloride and the high pressure oxygen treatment on the elderly dementia.Methods 82 cases of Alzheimer's disease(AD),and 93 cases of vascular dementia(VD) patients were randomly divided into 4 groups:high-pressure oxygen,donepezil hydrochloride,high-pressure oxygen + donepezil hydrochloride and piracetam group.The mini-mental state examination(MMSE),Wechsler Memory Scale(WMS),Life Functioning Scale(ADL) scores were evaluated and compared before a... |
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| Keywords: | Donepezil hydrochloride High pressure oxygen Elderly dementia |
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