Cytochrome P450 2E1 polymorphism and nasopharyngeal carcinoma development in Thailand: a correlative study |
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| Authors: | Narisorn Kongruttanachok Sairoong Sukdikul Surachai Setavarin Verachai Kerekhjanarong Pakpoom Supiyaphun Narin Voravud Yong Poovorawan Apiwat Mutirangura |
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| Institution: | (1) Genetics unit; Department of Anatomy, Thailand;(2) National Cancer Institute, Bangkok, Thailand;(3) Department of Otolaryngology, Thailand;(4) Medical Oncology unit, Thailand;(5) Viral Hepatitis Research Unit; Department of Medicine, Faculty of Medicine, Chulalongkorn University, Thailand |
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| Abstract: | Background Nasopharyngeal carcinoma (NPC) is a rare tumor in most parts of the world but occurs at relatively high frequency among people of Chinese descent. The cytochrome P450 2E1 enzyme (CYP2E1) is responsible for the metabolic activation of nitrosamines, and has been shown to be a susceptibility gene for NPC development in Taiwan RR = 2.6; 95%CI = 1.2-5.7]. Since there has been only one report of this link, it was decided to investigate the susceptibility of CYP2E1 to NPC development in other populations. Therefore, the correlation between the RsaI polymorphism of this gene and NPC was studied in-patients including Thai and Chinese in Thailand. The present study comprised 217 cases diagnosed with NPC and 297 healthy controls. |
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