新生儿先天性畸形248例相关因素分析

目的]探讨新生儿先天性畸形发生与孕夫妇、新生儿之间的相关因素。方法]搜集整理我院1997—2006年的248例先天性畸形新生儿资料,按1∶1病例-对照比例,进行对照研究和统计分析。结果]我院该时期先天性畸形儿的发生率为11.5‰(248/21548),先天性心脏病、运动系统肢体畸形、颅面部畸形居畸形类型的前三位。孕妇年龄、产检次数均影响新生儿先天性畸形的发生(P<0.05)。结论]我院新生儿先天性畸形的发生率及种类基本符合我国现状。先天性畸形的发生与孕妇年龄大、产检次数少等因素有关。加强产前保健,适龄生育等干预措施可减少先天性畸形儿的出生。

Analysis on relevant factors in 248 cases of neonatal congenital malformations

Objective ] To investigate the relevant risk factors of congenital malformations with their parents and neonatus themselves. Methods] The clinical data of 248 congenital malformation cases during 1997 - 2006 in our hospital were reviewed and analyzed as 1 ： 1 case-control study. The data were analyzed statistically. Resuits] The morbidity rate of congenital malformation was 11.5‰ during this peroid. Result of logistic analysis indicated that the maternal age, frequency of perinatal care were related to incidence of congenital malformation （ P 〈 0.05）. Conclusion] The morbidity rate and type of congenital malformation in our hospital was similar to the national feature. The relevant factors of congenital malformation including older maternal age and less times of perinatal care. It is suggested by our data that effective intervention measures such as intensive perinatal care, child bearing at appropriate age might decrease the incidence of congenital malformation.