帕金森病与饮茶的病例对照研究

目的探讨饮茶同原发性帕金森病(PD)的关系。方法采用以人群为基础的病例对照研究,调查在北京地区55岁以上PD患病率调查中确诊及2002年8月至2003年1月在北京协和医院帕金森研究中心诊治的病人共114例;以及性别、民族及居住地与其匹配的对照205例。采用统一的危险因素结构式问卷和诊断标准对所有对象的社会人口学资料和个人的生活习惯:饮茶、吸烟、饮酒及一级亲属的家族史因素与PD发病情况进行调查,应用单因素和多因素分析方法对有关因素进行分析。结果在饮茶与PD关系的单因素分析中,以非饮茶人群为对照,饮茶者患PD的比值比(OR)为0.23(95%CI:0.14,0.62;P<0.01)。经多因素的非条件Logistic回归分析后,饮茶者的OR值为0.199(95%CI:0.114,0.345;P<0.001)。结论北京地区居民中饮茶与帕金森病呈显著负相关联,为PD的保护性因素。

A case-control study on Parkinson''''s disease and tea drinking

Objective To explore the association between Parkinson's disease (PD) and tea drinking. Methods 114 PD cases and 205 controls to match on gender and race were recruited from ongoing PD prevalence survey among the elderly with more than 55 years and identified between August 2002 and January 2003 at the neurological clinic of Peking Union Hospital. The data on tea drinking were obtained and analyzed in a population-based case-control study by means of in-person questionnaire interview. A unified questionnaire of risk factors and diagnostic standards of PD was used to identify demographic characteristics, first-degree relative's family history and personal living habits of tea drinking, smoking, and alcohol drinking for all cases and controls. Then univariate and multivariate analysis were used to study the correlation between PD and tea drinking. Results With non-tea-drinkers as the reference category, OR value for PD in tea-drinkers was 0.23 (95%CI: 0.14, 0.62; P<0.01). After an unconditioned logistic regression analysis of multiple factors, OR was 0.199(95%CI: 0.114, 0.345; P <0.001) for tea drinkers. Conclusion The significant inverse association do exist between PD and tea drinking in Beijing residents, so tea drinking may be a protection factor against PD.