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| 乌司他丁可改善脓毒症大鼠的急性认知功能损害 | |
| 引用本文： | 郑李娜,王文,谭庆荣,杜可军,信玉昌,董海龙,尚磊,侯立朝. 乌司他丁可改善脓毒症大鼠的急性认知功能损害[J]. 神经解剖学杂志, 2011, 27(1): 29-33 |
| 作者姓名： | 郑李娜 王文 谭庆荣 杜可军 信玉昌 董海龙 尚磊 侯立朝 |
| 作者单位： | 1. 山西省人民医院麻醉科,太原,030012;第四军医大学:西京医院麻醉科,西安,710032 2. 第四军医大学:人体解剖学教研室,西安,710032 3. 第四军医大学:西京医院心身科,西安,710032 4. 第四军医大学:预防医学系,西安,710032 5. 第四军医大学:唐都医院麻醉科,西安,710032 6. 第四军医大学:西京医院麻醉科,西安,710032 7. 第四军医大学:统计学教研室,西安,710032 |
| 基金项目： | 国家自然科学基金(30471675,30672041) |
| 摘 要： | 目的:研究乌司他丁(UTI)在脓毒症大鼠模型中对急性认知功能损害的治疗作用.方法:通过对大鼠腹腔注射脂多糖(LPS,8或16 mg/kg)的方法,形成大鼠的脓毒症模型,并通过Morris水迷宫训练测试其空间学习能力.UTI治疗组在大鼠腹腔注射LPS 16 mg/kg后30 min给予UTI,通过Morris水迷宫测试其... |
| 关 键 词： | 脓毒症 认知 乌司他丁 大鼠 |
Urinary trypsin inhibitor attenuates acute cognitive impairment in septic rat |
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| Zheng Lina,Wang Wen,Tan Qingrong,Du Kejun,Xin Yuchang,Dong Hailong,Shang Lei,Hou Lichao. Urinary trypsin inhibitor attenuates acute cognitive impairment in septic rat[J]. Chinese Journal of Neuroanatomy, 2011, 27(1): 29-33 | |
| Authors: | Zheng Lina Wang Wen Tan Qingrong Du Kejun Xin Yuchang Dong Hailong Shang Lei Hou Lichao |
| Affiliation: | Zheng Lina1,2,Wang Wen3,Tan Qingrong4,Du Kejun5,Xin Yuchang6Dong Hailong2,Shang Lei7,Hou Lichao2(1.Department of Anesthesiology,Shanxi Provincial People's Hospital,Taiyuan 030012,2.Department of Anesthesiology,Xijing Hospital,3.Department of Human Anatomy,4.Department of Psychosomatics,5.School of Preventive Medicine,6.Department of Anesthesiology,Tangdu Hospital,7.Department of Statistics,Fourth Military Medical University,Xi'an 710032,China) |
| Abstract: | Objective:To investigate the effect of urinary trypsin inhibitor(UTI) on acute cognitive impairment in a rat model of sepsis.Methods:Intraperitoneal injection of lipopolysaccharide(LPS,8 or 16 mg/kg) was used to induce sepsis in adult Sprague-Dawley rats.We tested the spatial learning ability of rats through the Morris Water Maze(MWM) training.In the UTI-treated group,UTI was administrated at 30 min after LPS(16 mg/kg) injection,and the spatial learning ability was tested through the MWW training.Results:Af... |
| Keywords: | sepsis cognition urinary trypsin inhibitor rat |
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