CYP3A4 expression to predict treatment response to docetaxel for metastasis and recurrence of primary breast cancer |
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| Authors: | Kenichi Sakurai Katsuhisa Enomoto Sadanori Matsuo Sadao Amano Motomi Shiono |
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| Affiliation: | (1) Department of Radiation Oncology, Vermont Cancer Center, University of Vermont, Burlington, Vermont, USA |
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| Abstract: | Purpose Tumors expressing high levels of CYP3A4 are likely to have a poor treatment response to docetaxel (DOC), which is metabolized by CYP3A4. Tissue samples of recurrent breast cancer are sometimes hard to obtain just before treatment because the tumor is often difficult to access. Using immunohistochemistry, we measured CYP3A4 expression in primary lesions and compared their treatment responses to DOC with those of recurrent breast cancer lesions. |
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