| 同产ESBLs及AmpC酶肺炎克雷伯菌的耐药性分析 |
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| 引用本文： | 周庆,吕火祥,许玲英.同产ESBLs及AmpC酶肺炎克雷伯菌的耐药性分析[J].中华医院感染学杂志,2011,21(1):11-13. |
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| 作者姓名： | 周庆 吕火祥 许玲英 |
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| 作者单位： | 1. 浙江省海盐县人民医院检验科,浙江,海盐县,314300
2. 浙江省人民医院微生物室,浙江,杭州,310014 |
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| 摘 要： | 目的分析儿童感染同产ESBLs和AmpC酶肺炎克雷伯菌的情况及其耐药性,以指导临床合理用药。方法对2009年1月-2010年1月医院就医儿童分离肺炎克雷伯菌122株,采用PCR法检测ESBLs酶基因blaTEM,blaSHV、blaCTX-M-9群,AmpC酶基因blaDHA、blaACT/MIR;K-B纸片琼脂扩散法检测肺炎克雷伯菌对抗菌药物的敏感性。结果 122株肺炎克雷伯菌中单纯AmpC酶基因阳性菌株7株,阳性率5.7%,单纯ESBLs基因阳性菌株37株,阳性率30.3%,ESBLs和AmpC酶基因同时阳性菌株检出率为9.0%,非产ESBLs和AmpC菌株67株,检出率55.0%;同产ESBLs和AmpC酶肺炎克雷伯菌除了对亚胺培南和美罗培南敏感外,对其余β-内酰胺类抗菌药物和头孢菌素类高度耐药,产酶菌株耐药率明显高于非产酶菌株。结论儿童感染肺炎克雷伯菌产ESBLs和AmpC酶的情况已经出现,产酶菌株对常用β-内酰胺类抗菌药物耐药率较高,其主要原因是肺炎克雷伯菌产ESBLs和AmpC酶;临床治疗应根据药敏指导合理使用抗菌药物。
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| 关 键 词： | 肺炎克雷伯菌 产超广谱β-内酰胺酶 AmpC酶 耐药性 |
Drug resistance of both ESBLs and AmpC-producing klebsiella pneunomiae |
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| ZHOU Qing,L Huo-xiang,XU Ling-ying.Drug resistance of both ESBLs and AmpC-producing klebsiella pneunomiae[J].Chinese Journal of Nosocomiology,2011,21(1):11-13. |
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| Authors: | ZHOU Qing L Huo-xiang XU Ling-ying |
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| Institution: | ZHOU Qing,L(U) Huo-xiang,XU Ling-ying |
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| Abstract: | OBJECTIVE To investigate the prevalence and resistance of AmpC beta-lactamases and extended-spectrum betalactamases(ESBLs) produced by Klebsiella pneumoniae isolated from children.METHODS A total of 122 strains of K.pneumoniae were collected from the children from Jun 2009 to Jan 2010,using PCR method to detect ESBLs genes,blaTEM,blaSHV,blaCTX-M-9 groups and AmpC genes,DHA,ACT/MIR.K-B disk diffusion test was used to do the sensitivity test.RESULTS The positive rate of AmpC genes only,ESBLs genes only and bo... |
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