|
|||||
|
|
| 氟喹诺酮类药物对鲍氏不动杆菌防耐药变异浓度测定 | |
| 引用本文： | 豆梅琴,孙成春,公衍文.氟喹诺酮类药物对鲍氏不动杆菌防耐药变异浓度测定[J].中华医院感染学杂志,2011,21(5):849-851. |
| 作者姓名： | 豆梅琴 孙成春 公衍文 |
| 作者单位： | 1. 济南市传染病医院西药剂科,山东,济南,250021 2. 济南军区总医院药剂科,山东,济南,250031 3. 济南军区总医院检验科,山东,济南,250031 |
| 摘 要： | 目的研究4种氟喹诺酮类药物对鲍氏不动杆菌耐药突变株的选择能力,比较其防耐药变异能力。方法肉汤法富集1010CFU/ml鲍氏不动杆菌和34株临床分离菌,采用平板稀释法对加替沙星、左氧氟沙星、帕珠沙星和环丙沙星对鲍氏不动杆菌的MIC99、暂定防耐药变异浓度及防耐药变异浓度(MPC)进行测定。结果加替沙星、左氧氟沙星、帕珠沙星、环丙沙星对鲍氏不动杆菌的MPC分别为1.2、2.8、5.6和12.8μg/ml;细菌耐药选择指数分别为3.4、4、8和16μg/ml;加替沙星、左氧氟沙星、帕珠沙星和环丙沙星对34株鲍氏不动杆菌临床分离菌MPC值分别为0.5、1、8和4μg/ml,选择指数分别为4、4、8和8μg/ml。结论加替沙星和左氧氟沙星限制鲍氏不动杆菌耐药突变菌株的选择能力强于环丙沙星和帕珠沙星。 |
| 关 键 词： | 防耐药变异浓度 氟喹诺酮类 鲍氏不动杆菌 |
Mutant prevention concentrations of fluoroquinolones for acinetobacter baumannii |
|
| DOU Mei-qin,SUN Cheng-chun,GONG Yan-wen.Mutant prevention concentrations of fluoroquinolones for acinetobacter baumannii[J].Chinese Journal of Nosocomiology,2011,21(5):849-851. | |
| Authors: | DOU Mei-qin SUN Cheng-chun GONG Yan-wen |
| Institution: | DOU Mei-qin,SUN Cheng-chun,GONG Yan-wen(Jinan Infectious Disease Hospital,Jinan,Shandong 250021,China) |
| Abstract: | OBJECTIVE To measure the mutant prevention concentrations(MPC) in vitro of fluoroquino1ones for Acinetobacter baumannii and compare the capacity of fluoroquino1ones to prevent the resistant mutant strain.METHODS The A.baumannii strain ATCC19606 and 34 clinical isolates were enriched in broth,and the bacterial concentrations were adjusted to 1010 colony forming units per milliliter.The minimal inhibitory concentration(MIC),MIC for 99 of input cells(MIC99),provisional MPC(MPCpr) and MPC of gatifloxacin,levofl... |
| Keywords: | Mutant prevention concentration Fluoroquinolones Acinetobacter baumannii |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |