透视引导经皮细针穿刺活检肺癌假阴性的相关因素分析

目的探讨肺癌病灶经皮细针穿刺抽吸活检假阴性结果产生的相关因素和避免方法。资料与方法回顾性研究60例在电视透视下(有1例加用CT引导)行经皮针吸肺活检的病例．追踪肺穿刺细胞学结果与手术病理或临床随访结果。分类记录假阴性病灶的操作人员、病理结果、术中发现和病灶CT特征。结果发现假阴性14例(20．3％)。恶性病灶直径3～5cm，深度≥4cm，有坏死或继发感染．则易致穿刺假阴性。结论经皮细针穿刺抽吸活检肺内病灶时一定要仔细分析病灶特征并熟练掌握相应的穿刺技巧．尽量避免发生假阴性。

Factors Related to False-negative Results in Percutaneous Transthoracic Fine-needle Aspiration Biopsy in Lung Cancer

Objective To discuss the factors related to false-negative results in percutaneous transthoracic fine-needle aspiration biopsy in lung cancer and the ways to avoid such results. Materials and Methods 60 cases of fluoroscopy guided percutaneous needle biopsy for pulmonary lesions were retrospectively reviewed. The ultimate diagnoses were based on histological findings from surgery or follow-up. Data of the operators, histological results, in operation findings and imaging characteristics of the lesions were also recorded. Results There were 14 false-negative cases (20.3%) in all. When the lesion had a diameter between 3cm and 5cm, more deeply situated from body surface (more than 4cm), with necrosis and secondary infection exist, which were more possible to get a false-negative result.Conclusion The operator should analyze the characteristics of the lesions and try his best to master the appropriate operating skills to avoid false-negative result in percutaneous transthoracic fine-needle aspiration biopsy in lung cancer.