| 地塞米松对创伤性休克时外周血一氧化氮和内皮素—1的影响 |
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| 引用本文： | 赵勇 黄宗海 等. 地塞米松对创伤性休克时外周血一氧化氮和内皮素—1的影响[J]. 西北国防医学杂志, 2001, 22(3): 265-267 |
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| 作者姓名： | 赵勇 黄宗海 等 |
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| 作者单位： | [1]兰州军区兰州总医院，甘肃兰州730050 [2]第一军医大学珠江医院，广东广州510282 |
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| 摘 要： | 目的：了解地塞米松对创伤性休克时外周血一氧化氮和内皮素－1的影响。方法：复制兔创伤性休克模型，测定创伤前、后外周血内皮素－1和一氧化氮浓度变化并观察地塞米松对内皮素－1和一氧化氮浓度的影响。结果：创伤性休克时，对照组内皮素－1和一氧化氮浓度显著升高（P＜0.01）；治疗组内皮素－1浓度升高更加显著（P＜0.01），而一氧化氮氮浓度则明显降低（P＜0.01）。治疗组动物存活时间显著延长（P＜0.01）。结论：内皮素－1和一氧化氮参与了创伤性休克的病理损伤过程；地塞米松通过影响内皮素－1和一氧化氮的浓度变化来发挥其对休克的治疗作用。
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| 关 键 词： | 创伤性休克 内皮素－1 一氧化氮 地塞米松 |
| 文章编号： | 1007-8622(2001)03-0265-03 |
| 修稿时间： | 2000-11-06 |
The new mechanism of dexamethasone on treating traumatic shock |
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| ZHAO Yong,ZHAO Wu min,HUANG Zong hai,et al.. The new mechanism of dexamethasone on treating traumatic shock[J]. Medical Journal of National Defending Forces in Northwest China, 2001, 22(3): 265-267 |
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| Authors: | ZHAO Yong ZHAO Wu min HUANG Zong hai et al. |
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| Affiliation: | ZHAO Yong,ZHAO Wu min,HUANG Zong hai,et al . |
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| Abstract: | Objective:To observe the alteration of endothelin-1 and nitric oxide treating by dexamethasone on traumatic shock.Methods:By reconstructing a rabbit traumatic shock model,the changes of endothelin-1 and nitric oxide concentration in peripherial blood pre-and-post trauma were measured.Results:The concentration of endothelin-1 and nitric oxide in control group increased significantly.While in the treatment group,the concentration of endothelin-1 increased much higher than that in control group and the concentration of nitric oxide decreased.The survival time of treatment group was longer than that of control group.Conclusion:The results demonstrated that endothelin-1 and nitric oxide play a role in traumatic shock and dexamethasone has treatment effects on traumatic shock by altering the concentration of endothelin-1 and nitric oxide in peripherial blood. |
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| Keywords: | Traumatic shock Endothelin-1(ET-1) Nitric oxide(NO) Dexamethasone |
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