Ez rin 蛋白表达与乳腺癌临床病理特征的相关性研究

目的：研究Ezrin蛋白与乳腺癌临床病理特征的相关性及其对乳腺癌远处转移的影响。方法采用免疫组化染色法，检测86例乳腺癌患者及90例正常乳腺组织中Ezrin蛋白的表达。结果乳腺癌患者Ezrin蛋白阳性表达率为62．8％，明显高于良性病变患者的乳腺组织（14．4％），差异有统计学意义（ P＜0．01）；86例乳腺癌患者的Ezrin表达强度与患者年龄、病理类型和肿瘤直径无明显相关（P＞0．05），与伴有淋巴结转移及临床分期显著相关（P＜0．05）；乳腺癌远处转移的危险因素是临床分期和Ezrin蛋白阳性表达（P＜0．05）。结论 Ezrin与乳腺癌的增殖、侵袭和转移明显相关，可以作为乳腺癌远处转移的预测指标。

Relationship between expression level of Ezrin protein and clinicopathological features of breast carcinoma

Objective To assess the relationship between expression level of Ezrin protein and clinicopatholog-ical features of breast carcinoma ,and its effects on distant metastasis of breast carcinoma .Methods Immunohisto-chemical staining was used to detect the expression levels of Ezrin protein in 86 cases with breast cancer and 90 cases with normal breast tissues .Results In patients with breast carcinoma ,the positive expression rate of Ezrin protein was 62 .8% ,which was significantly higher than the 14 .4% in cases with normal breast tissues （P〈0 .01） .Expres-sion level of Ezrin was no significant correlated with age ,pathological type and tumor diameter in patients with breast carcinoma （P〉0 .05） ,but was significantly correlated with lymph node metastasis and clinical stage （P〈0 .05） . Clinical stage and positive expression of Ezrin protein were risk factors of distant metastasis of breast cancer （P〈0 . 05） .Conclusion Ezrin protein might be correlated with the proliferation ,invasion and distant metastasis of breast carcinoma ,which could be used as predictor of distant metastasis of breast carcinoma .