Tumor necrosis factor and interleukin-1β: suppression of food intake by direct action in the central nervous system |
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Authors: | Carlos R. Plata-Salam n, Yutaka Oomura,Yukihiro Kai |
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Affiliation: | Carlos R. Plata-Salamán, Yutaka Oomura,Yukihiro Kai |
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Abstract: | Intracerebroventricular microinfusion of recombinant human tumor necrosis factor (rhTNF) and recombinant human interleukin-1β (rhIL-1β) suppressed food intake in rats. Central infusion of heat-inactivated rhTNF and rhIL-1β, bovine serum albumin, heparin or transforming growth factor-β had no such effect. Central infusion of rhIL-1β did not affect the dipsogenic response to central administration of angiotensin II. Peripheral administration of rhTNF and rhIL-1β in doses equivalent to or higher than those administered centrally had no effect. Electrophoretically applied rhTNF and rhIL-1β specifically suppressed the activity of glucose-sensitive neurons in the lateral hypothalamic area. Glucose-insensitive neurons were little affected. The results suggest that TNF and IL-1β act directly in the central nervous system to suppress feeding, and this effect may be operative during acute and chronic disease. |
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Keywords: | Tumor necrosis factor Interleukin-1β Transforming growth factor-β Angiotensin II Food and water intake Rat Central nervous system Intracerebroventricular administration |
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