| 羟基喜树碱联合化疗方案治疗大肠癌60例临床观察 |
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| 引用本文： | 刘萍.羟基喜树碱联合化疗方案治疗大肠癌60例临床观察[J].中国肿瘤临床与康复,2004,11(4):313-314. |
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| 作者姓名： | 刘萍 |
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| 作者单位： | 郑州大学第二附属医院肿瘤科,河南郑州,450003 |
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| 摘 要： | 目的观察羟基喜树碱(HCPT)、氟尿嘧啶(5-Fu)、醛氢叶酸(CF)联合治疗晚期大肠癌的临床疗效.方法将60例大肠癌患者随机分成两组,分别采用HCPT 5-Fu CF方案及5-Fu CF方案化疗两个周期以上,评价其疗效及毒性.结果 HCPT 5-Fu CF组有效率50.0%,明显高于5-Fu CF组(23.3%,P<0.05).毒副反应主要为骨髓抑制、胃肠道反应及脱发.结论 HCPT 5-Fu CF方案治疗晚期大肠癌疗效高,毒副反应轻微.
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| 关 键 词： | 结直肠肿瘤/化学疗法 羟基喜树碱 氟尿嘧啶 醛氢叶酸 |
| 文章编号： | 1005-8664(2004)04-0313-02 |
| 修稿时间： | 2004年2月20日 |
Clinical observation on HCPT+5-Fu+CF in the treatment of 60 cases of colorectal cancer |
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| LIU Ping.Clinical observation on HCPT+5-Fu+CF in the treatment of 60 cases of colorectal cancer[J].Chinese Journal of Clinical Oncology and Rehabilitation,2004,11(4):313-314. |
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| Authors: | LIU Ping |
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| Abstract: | Objective To observe the clinical efficacy of HCPT 5 Fu CF in the treatment of colorectal cancer.Methods Sixty patients with colorectal cancer were randomized into two groups: experiment group(30 patients) received HCPT 5 Fu CF regimen; control group(30 patients) received 5 Fu CF regimen. The efficacy and toxicity were respectively measured after completion of two cycles of chemotherapy.Results The response in the experiment group (50.0%) was higher than that of the control group (23.3%, P <0.05).Conclusion The regimen of HCPT 5 Fu CF is effective in the treatment of colorectal cancer, and is well tolerated. |
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| Keywords: | Colorectal neoplasms/chemotherapy Hydroxycamptothecin Fluorouracil Leucovorin |
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