人体胃癌化学病因探讨——胃癌高发农村居民唾液、胃液硝酸盐、亚硝酸盐及其相互关系的分析研究

报告宁夏吴忠胃癌高发社队居民唾液胃液硝酸盐、亚硝酸盐、硫氰酸盐和胃液 pH、胃液内细菌生长情况以及胃粘膜活检的检测结果。结果表明:(1)该地不少居民(80%以上)胃液内有较多形成 N-亚硝基化合物的前体和条件,这可能是该地胃癌高发的直接原因;(2)胃液内亚硝酸盐含量以萎缩性胃炎最高,浅表性胃炎次之,正常人再次之,据此推论,在萎缩性胃炎患者胃内,N-亚硝基化合物之合成亦最多;(3)慢性胃炎时,唾液及胃液内亚硝酸盐无依从关系,胃液内之亚硝酸盐可能由胃内硝酸盐还原而成;(4)伴肠化或不伴肠化的萎缩性胃炎,胃液内硝酸盐、亚硝酸盐并无显著不同,N-亚硝基化合物的存在似与上述两型萎缩性胃炎的发生无直接关系。从病因学的角度讨论了萎缩性胃炎与胃癌的关系。

A Study of the Etiological Eactors of Human Gastric Carcinoma:Nitrate and Nitrite in Saliva and Gastric Juice of Residents in a Rural High-risk Region of Gastric Cancer

Biopsy of gastric mucosa,saliva and gastric juice nitrate and nitrite concentrations, as well as gastric pH and growuh condition of bacteria flora in stomach,were exa- mined and assayed in 237 rural inhabitants of a high gastric cancer mortality region of Wuzhong County,Ningxia. Data and histopathological findings showed that:(1)More than 80% of the 237 inhabitants seemed to be potentially liable to form N-nitroso compounds in their stomachs,which might become an important direct risk factor of gastric cancer. (2)The gastric juice nitrite concentration of atrophic gastritis was higher than that of superficial gastritis,the latter in turn was higher than those of normal stoma- ch inhabitants.It seems that the risk of synthesizing N-nitroso compounds in stoma- ch is greatest in atrophic gastritis,and least in normal stomach,postulating that N- nitroso compounds to be one of the etiological factors of gastric cancer and chronic gastritis.(3)In chronic gastritis,there was no correlation between nitrite concentra- tions of saliva and gastric juice;the nitrite of gastric juice seems to be the reductio- n product of nitrate,and this reaction seems to be influenced by pH and bacteria flora of gastric juioe.(4)In atrophic gastritis,whether complicated by intestinal me- taplasia or not,the difference between nitrite and nitrate concentrations of gastric juice did not appear to be statistically significant.It seems that there exists no direct relationship between the two above types of atrophic gastritis,as well as between N- nitroso compounds and formation of the two above types.