| 白细胞介素-6在上皮性卵巢癌中的表达及其意义 |
| |
| 引用本文： | 彭程,李敏,周颖,赵卫东,冯定庆,凌斌. 白细胞介素-6在上皮性卵巢癌中的表达及其意义[J]. 蚌埠医学院学报, 2009, 34(2): 117-119 |
| |
| 作者姓名： | 彭程 李敏 周颖 赵卫东 冯定庆 凌斌 |
| |
| 作者单位： | 1. 安徽医科大学附属省立医院妇产科, 安徽合肥 230001;2. 安徽省分子医学重点实验室, 安徽合肥 230001 |
| |
| 摘 要： | 目的:研究白细胞介素-6(interleukin-6,IL-6)在上皮性卵巢癌中的表达及其意义。方法:采用Western blot和RT-PCR方法检测20例上皮性卵巢癌组织和10例正常卵巢组织中IL-6蛋白及mRNA的表达。结果:上皮性卵巢癌组织中IL-6蛋白的表达较正常卵巢组织中低(P=0.000),差异有统计学意义;IL-6 mRNA在卵巢癌组织中的表达显著低于正常组(P=0.000)。结论:IL-6在上皮性卵巢癌组织呈低表达,为进一步探讨IL-6在上皮性卵巢癌发生、发展中的生物学作用提供了实验依据。
|
| 关 键 词： | 卵巢肿瘤 白细胞介素-6 信号转导及转录活化因子3 |
| 收稿时间： | 2008-08-13 |
The expression and significance of interleukin-6 in epithelial ovarian carcinoma |
| |
| PENG Cheng,LI Min,ZHOU Ying,ZHAO Wei-dong,FENG Ding-qing,LING Bin. The expression and significance of interleukin-6 in epithelial ovarian carcinoma[J]. Journal of Bengbu Medical College, 2009, 34(2): 117-119 |
| |
| Authors: | PENG Cheng LI Min ZHOU Ying ZHAO Wei-dong FENG Ding-qing LING Bin |
| |
| Affiliation: | 1. Department of Obstetrics and Gynecology, Anhui Provincial Hospital Affiliated of Anhui Medical University, Hefei Anhui 230001;2. Anhui Province Key Laboratory of Molecular Medicine, Hefei Anhui 230001, China |
| |
| Abstract: | Objective: To explore the expression and significance of interleukin-6 in epithelial ovarian carcinoma.Methods: Twenty epithelial ovarian carcinomas and ten normal ovarian tissues were examined by Western blot and RT-PCR in the protein and mRNA level.Results: The expression of IL-6 in epithelial ovarian carcinoma was obviously lower than that in normal ovarian tissue,both in protein and mRNA level,the difference had statistic significance(P=0.000).Conclusions: The low expression of interleukin-6 in epithelial ovarian carcinoma provides the experimental evidence for the further study on the the effect of interleukin-6 on the development of ovarian cancer. |
| |
| Keywords: | |
| 本文献已被 维普 万方数据 等数据库收录！ |
| 点击此处可从《蚌埠医学院学报》浏览原始摘要信息 |
|
点击此处可从《蚌埠医学院学报》下载全文 |
|
