碘化N-正丁基氟哌啶醇对大鼠心肌缺血再灌注损伤血流动力学的影响

目的　观察碘化N 正丁基氟哌啶醇 (N n butylhaloperidoliodide,F2 )对心肌缺血再灌注损伤的保护作用。方法　结扎大鼠冠状动脉左前降支 ,制成急性心肌缺血再灌注损伤模型 ,缺血前 5min ,舌下静脉推注F2 ,观察在急性缺血和再灌注状态下血流动力学的变化。实验结束时测量心肌梗死面积。结果　F2 能剂量依赖地改善大鼠心肌缺血再灌注后的血流动力学变化 ,SP、DP、AP、LVSP、LVDP、LVAP、±dp/dtmax均较缺血再灌注对照组及溶剂组升高 ,HR、LVEDP有所降低 ;同时可减少心肌梗死面积。结论　F2 对心肌缺血再灌注损伤有保护作用

Effects of N-n-butyl haloperidol iodide on the hemodynamics of myocardial ischemia-reperfusion injury in rats

AIM To evaluate the protective effect of N n butyl haloperidol iodide (F 2) on myocardial ischemia reperfusion injury. METHODS Myocardial ischemia reperfusion injury animal model was established by occluding rat's left anterior descending branch of coronary artery for 60 min and removing the ligation later to reperfuse for 60 min in vivo . Different doses of F 2 were administered by intravenous injection before the onset of ischemia for 5 min. The changes of hemodynamics were recorded during the experiment. Myocardial infarct sizes (% of area at risk) were calculated when the experiment was over. RESULTS F 2 ameliorated the hemodynamics of ischemia reperfusion injured myocardium in a dose dependent manner. The values of SP, DP, AP, LVSP, LVDP, LVAP, ±d p /d t max were obviously higher than those of the ischemia reperfusion control group, and the values of HR, LVEDP were lower. Furthermore, myocardial infarct sizes after 60 min of myocardial ischemia and 60 min of reperfusion of F 2 were reduced. CONCLUSION F 2 exerts an apparently protective effect against myocardial ischemia reperfusion injury.