脑出血血肿冲洗液炎性细胞因子动态变化的意义

目的:动态观察脑出血血肿冲洗液炎性细胞因子的变化及意义。方法:以2002年10月～2004年9月我科行微创颅内血肿清除术的60例高血压脑出血患者为研究对象,连续监测血肿冲洗液中肿瘤坏死因子(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)的动态变化。结果:高血压脑出血发病6h血肿冲洗液中即可检测出TNF-α、IL-1β、IL-6,在出血急性期呈现不同变化趋势。脑出血后24h及以后的各时间点TNF-α、IL-1β、IL-6含量与患者脑出血量呈正相关,脑出血量越大,TNF-α、IL-1β、IL-6含量越高。结论:高血压脑出血后炎性细胞因子参与了其后的病理过程,其变化水平与疾病的转归有关。

The significance of dynamic change of inflammatory cytokines in intracerebral hematomal fluid

Objective: To investigate the dynamic change of inflammatory cytokines in hematomal fluid after hypertensive cerebral hemorrhage and to explore the clinical significance. Methods: From 2002.10 to 2004.9, 60 patients accepted micro-injury operation in ICU were studied, and the changes of TNF-α, IL-1β,IL-6 in hematomal fluid were observed continuously. Results: TNF-α, IL-1β, IL-6 were observed in hematomal fluid at 6 hour after hypertensive cerebral hemorrhage and reached peaks at 48, 72 hours. We found that the TNF-α, IL-1β, IL-6 elevated Levels were significantly correlated to the volume of the hemorrhage measured at 24 hours and later time points. The bigger hemorrhage volumes, the higher the TNF-α, IL- 1β, IL-6 levels went up in the hematomal fluid. Conclusions: Inflammatory cytokines was involved in the pathological process of cerebral hemorrhage and was relevant to the prognosis of hypertensive cerebral hemorrhage.